Week 2 of Monday Night Football will feature the Saints taking on the Panthers. Here are predictions, picks, and odds for the game.
We are making our predictions for the New Orleans Saints vs. Carolina Panthers game based on the most favorable NFL odds, as we analyze the first matchup of Monday’s doubleheader.
The Carolina Panthers’ rookie QB Bryce Young, who was the top pick in the 2026 NFL Draft, suffered his first loss as a starter when the Panthers were defeated by their rival Atlanta Falcons last week. Young will remain in the NFC South as he prepares to face the 1-0 New Orleans Saints in a primetime Monday Night Football matchup.
To get a detailed view of the players participating in this game, be sure to explore our Saints vs. Panthers player props!
Make sure to check out our predictions for the Browns vs. Steelers matchup and player props for Monday night’s other game.
This is our top prediction for the Saints vs. Panthers game on Monday Night Football, based on odds from our top NFL betting sites. Confidence level is rated on a 1 to 5-star scale.
Prediction for the Monday Night Football matchup between the Saints and Panthers.
You can bet on under 40 points at -110 odds on DraftKings and FanDuel, receiving a four-star rating.
Editor’s update: The total has been revised to 39.5 at DraftKings and FanDuel.
In the last seven games played dating back to 2026, the Under has cashed in New Orleans and in each of the five previous meetings between these NFC South rivals. Another defensive battle is anticipated on Monday night.
The Saints’ offense has lacked consistency in recent years, with Derek Carr becoming the third quarterback in the last four seasons to win a season opener. However, the focus of this bet is on New Orleans’ defense, which has held nine consecutive opponents to 20 points or fewer, matching the franchise record set in 1991.
Young’s development as an NFL quarterback has been hindered by the unfavorable schedule set by the makers. Following his Week 1 loss to the Falcons, quarterbacks selected as the top overall pick since 2003 are winless in their first career start, with a record of 0-14-1.
Over the past two seasons, Panthers quarterbacks have ranked last in QBR (32), TD-INT ratio (30-34), and passing yards per game (183.4). The team also traded away their top wide receiver, D.J. Moore, to move up to the No. 1 pick. With this in mind, it will be a tough task for Young to lead the Panthers’ offense against the Saints’ defense, which has ranked ninth, fourth, and fifth in points per game allowed over the last three seasons, and fourth in opponent’s Total QBR last year.
In Week 1, New Orleans felt the absence of running back Alvin Kamara, who is suspended for two more games due to a personal conduct policy violation. The Saints only managed to run for 69 yards, averaging 2.6 yards per carry against the Titans. Their ground game is likely to face more challenges against the Panthers’ defense, which ranked 13th in defensive efficiency last season.
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The best odds for the Saints vs. Panthers game.
DraftKings, FanDuel (-110)
| DraftKings | FanDuel | BetMGM | Caesars | bet365 |
|---|---|---|---|---|
| 40 | 40 | 39.5 | 39.5 | 39.5 |
| Over (-110)/Under (-110) | Over (-110)/Under (-110) | Over (-110)/Under (-110) | Over (-110)/Under (-110) | Over (-110)/Under (-110) |
Under backers will find the best value with DraftKings and FanDuel, as they are the only two sportsbooks offering a total as high as 40. When comparing all top sports betting apps, neither charges more in juice for backing one side over the other, resulting in fairly even betting splits.
Monday Night Football odds for Saints vs. Panthers
Analysis of the odds for the Saints vs. Panthers matchup
The movement of the line during the week indicates that professional bettors placed their money on the Under. Caesars experienced the most significant change in total, starting at 42.5 and dropping to a low of 39 on Sunday. The total then increased to 41 before eventually settling at 39.5. FanDuel also saw a similar range, going from 39 to 42.5, but their total increased by a full point compared to just half a point when it reached 39.
According to our top sports betting sites, New Orleans is favored by 3 points. FanDuel is the only site offering odds on the underdog at +114 for +3. FanDuel is also the only site that did not offer odds for New Orleans at -3.5, while fans of the Panthers quickly placed their bets at other sites when +3.5 was available.
The moneyline odds for New Orleans range from -155 at DraftKings to -167 at BetRivers. Young aims to break the trend of poor performances by No. 1 overall draft picks in their second start, with the previous 26 players holding a record of 5-21 straight up and 10-15-1 against the spread in their second career starts.
Information about the Monday Night Football game
- The event will take place on Monday, September 18 at 7:15 p.m. Eastern Time.
- Location: Bank of America Stadium in Charlotte, NC
- How to watch: ESPN/ESPN2
- The weather is expected to be 80 degrees with a 13% chance of precipitation and a 6-mph NNW wind.
Prediction for Saints vs Panthers game on September 15, 2026, made at 8:59 p.m. Eastern Time.
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NFL Week 2 matchups
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