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Baker Mayfield of the Tampa Bay Buccaneers drops back to pass as we share our best Buccaneers vs. Lions prediction.
Baker Mayfield of the Tampa Bay Buccaneers drops back to pass during a game against the Green Bay Packers at Lambeau Field in Green Bay, Wisconsin. Photo by Stacy Revere/Getty Images via AFP.

We are analyzing our top NFL parlay predictions for Week 16, focusing on the best NFL odds available at our preferred sportsbooks as teams make their playoff push.

After Week 15, Baker Mayfield has led the Tampa Bay Buccaneers to the top spot in the NFC South with a 7-7 record. The upcoming matchup against the struggling Jacksonville Jaguars defense provides a great opportunity for Mayfield and the Buccaneers to exploit weaknesses and continue their success.

In other news, Atlanta Falcons running back Bijan Robinson is expected to receive more carries after his unexpected absence against the Carolina Panthers last week. Additionally, the game between the Dallas Cowboys and Miami Dolphins may not be as high-scoring as some anticipate.

Here are our top NFL Week 16 parlay predictions, along with our NFL Week 16 player props and NFL Week 16 predictions. Confidence levels are rated on a scale of 1 to 5 stars, with odds provided by our favorite NFL betting sites.

Top NFL Week 16 parlay picks

DraftKings is offering a parlay for NFL Week 16 with odds of +569.

Baker Mayfield is expected to throw for more than 233.5 passing yards with a strong likelihood, earning a four-star rating. (-115) ⭐⭐⭐⭐

Mayfield had a standout game last week, throwing for a season-high 381 yards in the Buccaneers’ victory over the Green Bay Packers. This was only his second time surpassing 300 yards in a game, and despite not reaching 202 yards in the previous three weeks, he is poised for another impressive performance this upcoming Sunday.

The Jaguars defense is struggling to contain opposing offenses. They are giving up an average of 256.6 passing yards per game this season, and three of the last four quarterbacks they have faced have thrown for over 300 yards against them.

Although the Jaguars managed to score just seven points against the Baltimore Ravens last week, they missed several chances to increase their score. However, they are expected to put up more points in their upcoming game, forcing Mayfield to throw throughout all four quarters. With the Jaguars’ strong secondary, Mayfield might just surpass 300 passing yards in this game.

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Bijan Robinson to rush for more than 58.5 yards (-120) with a four-star rating ⭐⭐⭐⭐

This season, Robinson has been a frustration for both bettors and fantasy owners. The talented rookie has not been used to his full potential in several advantageous matchups, such as the recent game against the Panthers. Despite his potential, he only had seven carries for 11 yards, while Tyler Allgeier received twice as many carries.

In order to secure his position as head coach of the Atlanta Falcons, Arthur Smith must utilize Robinson more in the upcoming game. Luckily for bettors, this game presents a very favorable matchup.

The Indianapolis Colts have the seventh-worst rushing defense in the NFL, allowing an average of 127.4 yards per game. Despite only having eight touches in the previous game, Robinson has been averaging nearly 20 touches in the last four games. With Taylor Heinicke as the quarterback and the Falcons fighting for a playoff spot, Robinson is expected to have a strong performance against the Colts’ weak run defense.

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The point total for the game between the Dallas Cowboys and Miami Dolphins is set at under 50, with a 4-star rating. (-105)

In reviewing the Week 16 schedule, one game stands out as a high-scoring contest. Despite 72% of bettors predicting a final score over 50 points, oddsmakers at top sports betting apps are lowering the total, with some setting it as low as 49.

Despite both defenses having inconsistent performances this season, the Cowboys rank fifth in scoring defense in the league, with the Dolphins following at 14th. Furthermore, the Dolphins have only allowed one of their last five opponents to score more than 20 points against them.

Both offenses have had difficulty performing against teams with winning records. The Dolphins have failed to score more than 20 points against any team over .500, and the Cowboys only managed to score 10 points against the Bills in their last game. While both offenses have the potential to score high, they are expected to face challenges this Sunday.

Parlay for NFL Week 16: +569 odds on DraftKings.

Parlay picks for Week 16 of the NFL were made on Friday at 11:07 a.m. ET.

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