LSU vs. Iowa Prediction & Odds

Caitlin Clark of the Iowa Hawkeyes shoots against Jaylyn Sherrod of the Colorado Buffaloes during the Sweet 16 round of the NCAA Women's Basketball Tournament. We expect a high-scoring game in our LSU vs. Iowa prediction & odds. — Caitlin Clark of the Iowa Hawkeyes shoots against Jaylyn Sherrod of the Colorado Buffaloes during the Sweet 16 round of the NCAA Women’s Basketball Tournament. Photo by Sarah Stier/Getty Images via AFP.

Caitlin Clark and the Iowa Hawkeyes are set to take on the LSU Tigers in a highly anticipated rematch of the 2023 women’s NCAA Tournament final. We are here to provide our prediction and best bet for the LSU vs. Iowa game, using the top Women’s March Madness odds available.

On Monday, the top-ranked Iowa Hawkeyes (32-4) will seek revenge against the third-seeded LSU Tigers (31-5) in the Elite Eight. Led by senior standout Caitlin Clark, the Hawkeyes are determined to avenge their loss in last season’s NCAA Tournament final. The game will start at 7:15 p.m. ET at MVP Arena in Albany, N.Y.

According to our top sports betting sites, Iowa is favored by 2 points in a matchup between the two highest-scoring offenses in the nation. With Clark and LSU’s Angel Reese at the forefront, anticipate a high-scoring game between these top contenders in the women’s March Madness odds.

As we analyze player props for Caitlin Clark and make our March Madness predictions, we present our top pick for the LSU vs. Iowa game (betting odds sourced from the best March Madness betting sites, confidence level rated on a scale of 1 to 5 stars).

Game information for LSU (3) vs. Iowa (1) matchup

When: Monday, April 1
The game starts at 7:15 p.m. Eastern Time.
Location: MVP Arena in Albany, New York.
How to watch: ESPN
Top pick: Iowa -2 with odds of -110 from DraftKings.

LSU vs. Iowa odds

Teams	Moneyline	Spread	Total
Iowa	-130	-2 (-110)	Over: 168.5 (-110)
LSU	+110	+2 (-110)	Under: 168.5 (-110)

The odds provided by DraftKings as of 11:15 a.m. ET.

LSU vs. Iowa prediction

Over 168.5 ⭐⭐⭐⭐

The most favorable odds are -110 on DraftKings.

Iowa and LSU lead the nation in scoring, with Iowa’s Caitlin Clark favored to win the women’s Wooden Award due to her exceptional scoring skills. Lisa Bluder’s Hawkeyes are first in the country in points per game at 91.9, with Clark averaging 31.7 points per game, the highest in the sport.

Iowa, led by Clark, ranks second in the nation in field goal percentage (50%), first in 3-pointers made per game (11.0), and first in 2-point percentage (60%). Clark’s playmaking ability has been instrumental in Iowa’s success during the tournament, as she is averaging 9.3 assists per game. With scoring threats like Stuelke and Martin, Iowa has proven to be a dangerous team in March Madness.

Iowa’s offense is the driving force behind its success as one of the top programs in the country. However, the team’s defense is a weak spot that LSU can exploit. With the Tigers boasting a high-scoring offense that ranks second in the nation with 85.9 points per game, they have the talent to capitalize on Iowa’s defensive vulnerabilities. The Hawkeyes defense allows the 40th most field goals per game (26.2) and the 12th most 3-pointers (7.9), which could be a significant advantage for LSU.

Iowa will struggle to defend against the size and strength of Reese, LSU’s top scorer and rebounder with 18.7 points and 13.2 rebounds per game. She is the main reason why the Tigers rank second in the nation in 2-pointers made per game (26.4) and lead in free throw attempts (27.3 per game). With talented shooters like Mikaylah Williams, Hailey Van Lith, and Flau’jae Johnson all shooting over 34% from three, LSU has the weapons to exploit Iowa’s weak perimeter defense.

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Analysis of the spread and Over/Under for the LSU vs Iowa game.

Different sports betting apps have varying opinions on how much Iowa should be favored in the championship game rematch. BetMGM has the Hawkeyes favored by up to 2.5 points (-110), while FanDuel has Iowa at -1.5 (-118). It is unlikely that the spread will exceed 2.5 or drop below 1.5 before the game begins.

All of our top live betting sites are in agreement on the Over/Under for this game, setting it at 168.5. Although this number may appear high, it could increase to 170.5 before tip-off. This is why we recommend taking the Over at 168.5 with -110 odds. With these odds, there is a 52.38% chance of the Over hitting, according to our odds calculator. A $10 bet would result in a $9.09 profit.

Prediction for the LSU vs. Iowa game was made on Monday at 10:15 a.m. ET.

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Written By:
Richardson Lilliana

Rob is a Publishing Editor at Underscoreg Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining UnderscoregReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.