Week 3 NFL Best Bets: Can the Cowboys and Chiefs Maintain their Dominance as Heavy Favorites?
As Week 3 of the NFL season unfolds, there are currently nine teams with perfect records and nine teams still seeking their first win. We are here to provide some of our top NFL Best Bets for Week 3, taking into consideration the latest NFL odds.
During Week 3, the favorites to win among the nine winless teams are the New England Patriots, Los Angeles Chargers, and Cincinnati Bengals. The Patriots stand out with a 14-game winning streak against the New York Jets, despite starting the season 0-2 for the first time since 2001.
It was a dream come true for live bettors last week, with four teams coming from behind by 10 or more points to secure wins.
Check out our top NFL bets and predictions for Week 3, with odds from the leading NFL betting sites. Our picks are rated on a scale from 1 to 5 stars based on confidence.
Week 3 NFL top picks: Best bets
- Keenan Allen is a strong bet to score a touchdown at any time, with odds of +140 on bet365. ⭐⭐⭐⭐
- Nico Collins expected to have more than 53.5 receiving yards against the Jaguars, odds -110 on bet365 ⭐⭐⭐⭐
- James Conner is expected to have less than 54.5 rushing yards against the Cowboys, with odds of -110 on bet365. This bet is rated four stars.
- Chiefs are favored by 12.5 points against the Bears, with odds of -110 at BetMGM and Caesars. This matchup is rated four stars.
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NFL Schedule and Odds for Week 3
(Odds via Caesars)
- The Detroit Lions are favored by 3 points in their matchup against the Atlanta Falcons.
- The Green Bay Packers are favored by 2 points over the New Orleans Saints.
- The Buffalo Bills are favored by 6.5 points against the Washington Commanders.
- The Baltimore Ravens are favored by 7.5 points in their matchup against the Indianapolis Colts.
- The Las Vegas Raiders are favored by 2.5 points over the Pittsburgh Steelers.
- The Philadelphia Eagles are favored by 5 points in their matchup against the Tampa Bay Buccaneers.
- The Jacksonville Jaguars are favored by 8.5 points over the Houston Texans.
- The Cleveland Browns are favored by 3.5 points in their matchup against the Tennessee Titans.
- New England Patriots are favored by 2.5 points in their matchup against the New York Jets.
- The Miami Dolphins are favored by 6.5 points in their matchup against the Denver Broncos.
- The Minnesota Vikings are favored by 1 point in their matchup against the Los Angeles Chargers.
- The Seattle Seahawks are favored by 6.5 points in their matchup against the Carolina Panthers.
- The Dallas Cowboys are favored by 12.5 points in their matchup against the Arizona Cardinals.
- The Kansas City Chiefs are favored by 13 points in their matchup against the Chicago Bears.
- The Philadelphia Eagles are favored by 5 points against the Tampa Bay Buccaneers.
- Cincinnati Bengals are favored by 3 points in their match against the Los Angeles Rams.
Week 3 NFL Predictions: What to Expect
Keenan Allen is a strong pick to score a touchdown at any time, with odds of +140 on bet365. ⭐⭐⭐⭐
The upcoming game between the Los Angeles Chargers and Minnesota Vikings is the only one this week with a projected total above 50 (54). We are eager to select one of the top skill-position players from this matchup to score a touchdown.
Allen had an impressive performance in his last game, with 10 targets, eight receptions, 111 receiving yards, and two touchdowns. This season, he is being utilized in a new way, with his air yards per target at a high of 10.7. He is currently on track to reach 1,600 yards and is playing for a team that made NFL history by starting 0-2 despite scoring over 50 points and having zero turnovers in the first two games.
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The Chargers are currently ranked last in total defense and have given up the most touchdowns. They are going up against Kirk Cousins, who is the first quarterback in NFL history to start 0-2 despite having a completion percentage of at least 70%, over 700 passing yards, and six or more passing touchdowns in the first two games of a season. As a result, we anticipate that Los Angeles will need to focus on offense and target their top wide receiver consistently throughout the game.
The +140 odds offered by bet365 stand out as the top choice when comparing various sports betting apps. Our expert, Green Finnian, is also leaning towards predicting the Over in the Chargers-Vikings game.
Nico Collins is favored to have over 53.5 receiving yards against the Jaguars, with a four-star rating from bet365 at -110 odds.
The fact that the Houston Texans are the only team in the NFL with three wide receivers in the top 35 of fantasy points scored would surprise even the most knowledgeable fantasy football experts. This achievement can be attributed to quarterback C.J. Stroud, who has thrown 91 passes so far this season, ranking third in the league. Furthermore, Stroud’s 58 completions in his first two starts are the second-most by a rookie since at least 1950.
Collins has thrived in Houston’s high-volume passing offense, receiving 24% of the team’s targets and nearly half of their air yards. He has recorded six receptions of 20-plus yards, the second-most in the league. Collins is averaging 10 targets and 113 yards per game, and will face the Jacksonville Jaguars who rank in the top third for yards allowed to wide receivers.
This play is a strong four-star pick, with the Jaguars being 9-point favorites against the Texans, who have a losing record of 0-10 SU in their last 10 games as underdogs of seven points or more. This sets Collins up for success in the passing game with a negative game script. Our expert Green Finnian is confident that Collins will have a big day in his prediction for the Texans-Jaguars matchup.
All of our top sports betting sites have agreed on a line of 53.5, with this being the most affordable Over option available. For further information, be sure to explore our Week 3 NFL predictions.
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Bet365 has James Conner with under 54.5 rushing yards against the Cowboys at odds of -110, with a four-star rating.
The Dallas Cowboys defense has been outstanding, only allowing 10 points in the first two games of the season. This is the lowest amount of points allowed among teams with 10 or more sacks and five or more interceptions in the first two games since 1963. Additionally, the Cowboys lead the NFL in scoring, quarterback rating, turnover differential, and have had the most drives of 10 or more plays. These factors will likely hinder James Conner, as the Arizona Cardinals may be playing from behind for most of the game. As a result, we predict that the Cowboys will cover the spread in their matchup against the Cardinals.
The defense of the Dallas Cowboys has been extremely successful in shutting down top running backs this season. They held Saquon Barkley to just 63 total yards and limited the powerful Jets backfield, led by Breece Hall and Dalvin Cook, to only 3.2 fantasy points in their games. Dallas has only allowed 89 rushing yards to opposing running backs in two games, indicating that even a skilled runner like Conner will struggle to find room to run against this tough defense.
Since many top sportsbooks are charging -115 for betting on the Under, we are turning to bet365 to pay the regular juice for the same total.
The Chiefs are favored by 12.5 points against the Bears with odds of -110 from BetMGM and Caesars. This is a four-star rated bet.
The Kansas City Chiefs and the Cowboys are both favored by the largest margin in Week 3, but even with a 12.5-point spread, it seems too low against the struggling Chicago Bears. The Bears have lost 12 consecutive games and have only covered in one of their last 10. However, in our prediction for the Chiefs-Bears matchup, we anticipate Justin Fields showcasing his scrambling abilities.
The Bears have suffered 12 consecutive road losses and have given up 25 or more points in each game. In five of their last eight games, Chicago has allowed opposing quarterbacks to score 22 or more fantasy points. This presents a great chance for the Chiefs to kickstart their offense after two sluggish beginnings.
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Patrick Mahomes has thrown 56 of his 80 pass attempts within 10 yards of the line of scrimmage, with 87% of his passing yards coming after the catch. He is close to reaching 25,000 pass yards and 200 passing touchdowns for his career. Head coach Andy Reid will likely try to help him achieve these milestones at home before the team hits the road next week. Green Finnian predicts a lot of excitement in Mahomes’ prop picks.
Bears defensive coordinator Alan Williams resigned suddenly on Wednesday, causing the team to drop to a four-star rating. The team’s Defensive Efficiency ranking fell to 28th after two games. Quarterback Justin Fields also made controversial comments about the team’s play-calling. Furthermore, starting left tackle Braxton Jones is out with a neck injury and placed on injured reserve.
NFL top picks were placed on 9/21/2026 at 6:59 a.m. ET.
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NFL betting odds pages
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Related pages
- Top Sports Betting Sites with the Best Promotions (For U.S. Customers Only)
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