Week 10 NFL Defensive Prop Bets: Expert Picks and Predictions
Check out our top NFL defensive player prop predictions for Week 10. We always look for the most favorable NFL odds from our trusted prop betting sites when making our picks.
It is a well-known fact that offensive players often dominate the spotlight in the NFL, overshadowing their defensive counterparts. Nevertheless, there are also exciting prop bets available for defensive players on our top sports betting sites.
Three standout defenders are set to have a major impact in Week 10, bringing an extra level of anticipation for bettors. These defensive stars are predicted to play a crucial role in determining the results of the games, making them essential players to keep an eye on as they aim to make game-altering plays that could shift the course of the matchups.
Here are our top NFL defensive player prop predictions for Week 10, to go along with our NFL Week 10 predictions and best bets. We have assessed the odds from our preferred NFL betting sites and assigned a confidence rating on a scale of 1 to 5 stars.
Predictions for defensive plays in Week 10 of the NFL.
- Roquan Smith is expected to record over 9.5 tackles and assists, with odds of +102 according to Caesars. This bet is rated with four stars.
- Bet on Danielle Hunter getting more than 0.75 sacks at -110 odds on DraftKings with a five-star rating.
- Kenny Moore II to have more than 0.5 interceptions (+600 odds on bet365) ⭐⭐⭐⭐
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Defensive player props
Bet on Roquan Smith to have over 9.5 tackles+assists at +102 odds with Caesars. This bet is rated 4 stars.
Smith comes from a lineage of talented Baltimore linebackers and currently ranks in the top five in the league for total tackles with 87. In 2026, he is averaging 9.6 tackles and assists per game. Smith has recorded at least 10 combined tackles in five out of nine games, one of which was against the Browns in Week 4. Baltimore will face the Browns again in Week 10.
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In 2026, Cleveland leads the league in offensive plays per game with an average of 71.6. The Browns’ opponents have had 10 players record at least 10 total tackles in their games.
Furthermore, in their 2026 season, the Ravens have been allowing an average of 68.8 offensive plays per game when playing at home, giving Smith ample opportunities to make an impact.
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Bet on Danielle Hunter to get more than 0.75 sacks at -110 odds on DraftKings with a high confidence rating of five stars.
Hunter is currently at the top of the leaderboard with 10 sacks, leading his league. In Week 9, the Vikings linebacker broke his streak of four consecutive games with at least one sack by not getting one against the Falcons. However, he has only failed to record a sack in two out of nine games so far in 2026. Smith is just half a sack away from surpassing his total number of sacks from the 2026 season.
He is now up against Derek Carr, who has been sacked 19 times in 2026. Carr has been taken down behind the line of scrimmage in six out of nine games. However, Hunter will have to work harder to achieve this Over, considering the Saints’ offensive line has only allowed two sacks in the past three weeks.
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Kenny Moore II to have at least one interception (+600 odds on bet365) ⭐⭐⭐⭐
In Week 9, Moore boosted his interception tally by snagging two passes thrown by Carolina quarterback Bryce Young. With a total of three interceptions, Moore currently leads the Colts in picks. Alongside safety Julian Blackmon, Moore is one of only two defenders on the team with multiple interceptions so far in the 2026 season.
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The Colts are set to take on Mac Jones, the quarterback for the New England Patriots, who has thrown nine interceptions so far this season. Jones is currently tied with three other players for the most interceptions thrown. In seven out of his nine games, the former Alabama quarterback has been intercepted, including three of his last four games.
Defensive player prop selections were made on 11/09/2026 at 11:30 p.m. ET.
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