Week 2 NFL Upset Picks and Predictions: Seahawks and Patriots Feeling Desperate

Our Week 2 NFL upset picks, featuring the Seattle Seahawks, New England Patriots, and Jacksonville Jaguars, are determined by analyzing the top NFL odds provided by our preferred sports betting apps. The Seahawks and Patriots are looking to avoid an 0-2 start in order to keep their playoff aspirations alive, while the Jaguars are striving to improve to 2-0 and solidify their status as contenders in the AFC.

Despite the parity that is a common feature in the NFL, a team’s chances of making it to the Super Bowl can quickly diminish with a slow start. Since 1990, less than 12% of teams that have started 0-2 have gone on to make the postseason. The Seattle Seahawks and New England Patriots are hoping to avoid being part of that statistic after their performances in Week 2.

This week, both the Seahawks and Patriots find themselves in a dire situation as they try to bounce back from losses in Week 1. Additionally, there is potential for betting against top teams like the Kansas City Chiefs, which many bettors may not have considered, as these teams face the possibility of starting the season with two straight losses.

Taking that perspective into consideration, here are our top NFL upset selections for Week 2 (odds sourced from our preferred NFL betting platforms; confidence level rated on a scale of 1 to 5 stars).

Surprising Week 2 NFL Predictions

• Seahawks are the underdogs with +195 odds against the Lions ⭐⭐⭐
• Jaguars are the underdogs with odds of +155 according to bet365, facing off against the Chiefs. ⭐⭐⭐
• The Patriots are underdogs at +140 odds against the Dolphins.

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NFL upset predictions

Seahawks are favored to win against the Lions, with a moneyline of +195 on DraftKings. ⭐⭐⭐

The Seahawks were far from looking like NFC West title contenders in Week 1, suffering a 30-13 defeat to the Los Angeles Rams in their most one-sided home loss in six years. Seattle seemed to underestimate the Rams, a team expected to compete with Arizona for the bottom of the NFC, as evidenced by quarterback Geno Smith’s observation that the Rams appeared to be playing with more intensity. However, the Seahawks need to be fully focused in their upcoming game to prevent their first 0-2 start since 2018.

Detroit’s bandwagon is growing after a victory in Kansas City, but it’s worth noting that the Chiefs were missing key players Travis Kelce and Chris Jones. Despite this, Kansas City could have won if not for numerous drops by their receivers, including a crucial pick-six that slipped through Kadarius Toney’s hands.

Do the Lions deserve to be the favored team at home in this situation? Absolutely. However, the opportunity to bet on the motivated Seahawks with nearly a 2:1 return at DraftKings is too enticing to ignore.

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Jaguars are favored to win against the Chiefs with a moneyline of +155 according to bet365. This game is rated three stars.

The reigning Super Bowl champions, the Chiefs, are unlikely to begin the season with a 0-2 record. This mindset is shared by most bettors, creating a chance to bet on the home underdog Jaguars at a lucrative plus-money price. Jacksonville gave Kansas City a tough challenge in the playoffs last year and seems even stronger now with the addition of receiver Calvin Ridley, who had an impressive performance in Week 1 with eight receptions for 101 yards and a touchdown in their win against Indianapolis.

After missing Kelce and Jones in the first game against Detroit, the Chiefs may have both players back for the upcoming game against the Jags. However, there are concerns about their effectiveness. Kelce only participated in limited practice on Wednesday and Jones may need some time to get back to his best form after his contract holdout. Without Kelce as his main target, Patrick Mahomes struggled in the previous game, throwing for 226 yards on 21 of 39 passes. The lack of depth in receiving options for K.C. was also evident in that game.

The Jaguars have been successful in their last six home games as underdogs, winning and covering each time with an average margin of victory of nine points. On the other hand, Kansas City has struggled in September games, going 1-6 against the spread in their last seven outings. If the +155 return isn’t enticing enough to bet against the Chiefs, taking Jacksonville +3.5 on the spread in what should be a closely fought game is also a tempting option.

Patriots are favored on the moneyline against the Dolphins (+140 odds through Caesars) with a four-star rating.

In Week 1, one of the most deceiving results was the Patriots’ 25-20 loss to the Philadelphia Eagles. Despite falling behind early due to two turnovers, New England held the Eagles to just three field goals for the remainder of the game. They were just 20 yards away from scoring the potential game-winning touchdown in the final minute. Throughout the game, the Patriots nearly doubled Philadelphia’s passing yards and had a 24-17 advantage in first downs.

Miami’s offense was the star of the show in their thrilling victory over the Los Angeles Chargers last week, with Tua Tagovailoa throwing for an impressive 466 yards, 215 of which went to Tyreek Hill. However, the New England Patriots’ secondary will pose a greater challenge, and their running game could dominate against a Miami defense that gave up 233 rushing yards and three touchdowns in their last game.

Expect New England to defeat Miami for the 13th time in their last 15 meetings at Foxborough.

NFL upset predictions were made on September 14, 2026 at 10:20 a.m. Eastern Time.

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