Week 2 of the NFL features odds and betting lines including spreads, moneylines, and over/unders.
In Week 2 of the NFL season, the spotlight will be on the Kansas City Chiefs and Jacksonville Jaguars as they face off in a rematch of their AFC Divisional playoff game. Let’s examine the Week 2 odds and betting lines from top NFL betting sites.
The Jacksonville Jaguars made strides towards becoming a Super Bowl contender last season by reaching the AFC Divisional round of the playoffs, although they were ultimately defeated by the Super Bowl champion Kansas City Chiefs. They continued their momentum in the 2026 season with a 31-21 victory over their rival Indianapolis Colts in Week 1.
In Week 2 of the season, Trevor Lawrence, Doug Pederson, and their team will have another opportunity to demonstrate their potential as true contenders for the Lombardi Trophy when they welcome the Chiefs to TIAA Bank Field.
The Chiefs are currently favored by 3.5 points in their road matchup against the Jaguars. Could Week 2 be the moment when the Jaguars make their mark by defeating the dominant Chiefs, who have controlled the AFC in recent years?
Week 2 NFL odds and betting lines
For optimal results when wagering on NFL markets, it is beneficial to access the NFL odds promptly and attempt to outsmart any fluctuations in the lines. Waiting until the last minute on Sunday to finalize your NFL picks can make it challenging to pinpoint advantages and secure the most favorable price for your chosen bet.
It is crucial to begin monitoring the NFL opening odds each week early on in order to increase your chances of success in sports betting in the long run.
Top NFL Week 2 betting lines
| Game | Opening spread (Sep. 6) | Spread (Sep. 9) | Spread (Sept. 11) | Spread (Sept. 15) | Spread (Sept. 17) |
|---|---|---|---|---|---|
| Vikings vs. Eagles | Eagles -7 | Eagles -7 | Eagles -7.5 | Eagles 34-28 | |
| Chiefs vs. Jaguars | Chiefs -2.5 | OTB | Chiefs -2.5 | Chiefs -3.5 (+100) | Chiefs 3.5 (-105) |
| Colts vs. Texans | Texans -1.5 | Texans -1.5 | Texans -1.5 | Texans -1 | Texans -1 (-110) |
| Packers vs. Falcons | Falcons -1.5 | Falcons -1.5 | Packers -1 | Falcons -1.5 | Falcons -3 (-105) |
| Seahawks vs. Lions | Lions -3 | OTB | Lions -5.5 | Lions -4.5 (-105) | Lions -4.5 (-110) |
| Raiders vs. Bills | Bills -9.5 | Bills -9.5 | Bills-10 | Bills -8.5 | Bills -8 (-110) |
| Ravens vs. Bengals | Bengals -3.5 | Bengals -3.5 | Bengals -3 | Bengals -3 (-120) | Bengals -3.5 (-105) |
| Chargers vs. Titans | Chargers -3 | Chargers -3.5 | Chargers -3 | Chargers -3 (+100) | Chargers -2.5 (-120) |
| Bears vs. Buccaneers | Bears -1.5 | Bears -1 | Buccaneers -3 | Buccaneers -2.5 | Buccaneers -2.5 (-120) |
| 49ers vs. Rams | 49ers -6 | 49ers -6 | 49ers -7 | 49ers -7.5 (-105) | 49ers -7 (-115) |
| Giants vs. Cardinals | Giants -5.5 | Giants -5.5 | Giants -4.5 | Giants -4 | Giants -4 (-110) |
| Jets vs. Cowboys | Cowboys -3 | Cowboys -3 | Cowboys -3 | Cowboys -9 | Cowboys -8.5 (-110) |
| Commanders vs. Broncos | Broncos -3.5 | Broncos -3.5 | Broncos -3.5 | Broncos -3.5 | Broncos -3.5 (-110) |
| Dolphins vs. Patriots | Dolphins -2 | Dolphins -2.5 | Dolphins -2 | Dolphins -3 (-105) | Dolphins -2.5 (-115) |
| Saints vs. Panthers | Saints -1.5 | Saints -2 | Saints -3 | Saints -3 | Saints -3 (-105) |
| Browns vs. Steelers | Steelers -1 | Steelers -1 | Browns -1 | Browns -2.5 | Browns -2.5 (-110) |
The New York Jets surprised everyone with an overtime victory against the Buffalo Bills on Monday Night Football in Week 1. Their win was sealed with a dramatic punt return for a touchdown. Despite their 1-0 record, the news that Zach Wilson will be the starting quarterback for the rest of the season, following Aaron Rodgers’ Achilles injury, is beginning to set in.
At first, the Cowboys were only favored by 3 points over the Jets. But with the confirmation of Wilson as the starting quarterback, the spread has now increased to Cowboys -9.
Top NFL Week 2 moneyline bets
| Game | Moneyline (Sept. 6) | Moneylines (Sept. 12) | Moneylines (Sept. 15) | Moneylines (Sept. 17) |
|---|---|---|---|---|
| Vikings vs. Eagles | Eagles (-298) | Eagles (-290) | Eagles 34-28 | |
| Seahawks vs. Lions | Lions (-142) | Lions (-230) | Lions (-225) | Lions (-205) |
| Colts vs. Texans | Texans (-115) | Colts (-125) | Texans (-120) | Texans (-118) |
| Raiders vs. Bills | Bills (-355) | Bills (-395) | Bills (-395) | Bills (-360) |
| Bears vs. Buccaneers | Bears (-122) | Buccaneers (-155) | Buccaneers (-135) | Buccaneers (-142) |
| Chargers vs. Titans | Chargers (-166) | Chargers (-162) | Chargers (-148) | Chargers (-142) |
| Ravens vs. Bengals | Bengals (-175) | Bengals (-170) | Bengals (-170) | Bengals (-170) |
| Packers vs. Falcons | Falcons (-125) | Packers (-118) | Falcons (-120) | Falcons (-135) |
| Chiefs vs. Jaguars | Chiefs (-155) | Chiefs (-155) | Chiefs (-185) | Chiefs (-180) |
| Giants vs. Cardinals | Giants (-205) | Giants (-185) | Giants (-218) | Giants (-205) |
| 49ers vs. Rams | 49ers (-198) | 49ers (-355) | 49ers (-340) | 49ers (-325) |
| Commanders vs. Broncos | Broncos (-192) | Broncos (-175) | Broncos (-180) | Broncos (-185) |
| Jets vs. Cowboys | Cowboys (-166) | Cowboys (-395) | Cowboys (-440) | Cowboys (-425) |
| Dolphins vs. Patriots | Dolphins (-130) | Dolphins (-135) | Dolphins (-155) | Dolphins (-142) |
| Saints vs. Panthers | Saints (-122) | Saints (-166) | Saints (-162) | Saints (-155) |
| Browns vs. Steelers | Steelers (-115) | Browns (-125) | Browns (-135) | Browns (-142) |
What’s even better than one game on Monday Night Football? Two games! In Week 2, we’ll be treated to an NFC South showdown between the New Orleans Saints and the Carolina Panthers, as well as an AFC North rivalry match-up between the Cleveland Browns and Pittsburgh Steelers.
Both divisional games scheduled for primetime are predicted to be tightly contested. The Saints are favored at -162 on the moneyline, while the Browns hold a slight edge at -135 over the Steelers.
Top NFL Week 2 Over/Under Picks
| Game | Over/Under (Sept. 9 – bet365) | Over/Under (Sept. 11) | Over/Under (Sept. 15) | Over/Under (Sept. 17) |
|---|---|---|---|---|
| Vikings vs. Eagles | 48.5 (-110/-110) | 48.5 (-110/-110) | Eagles 34-28 | |
| Ravens vs. Bengals | 47.5 (-110/-110) | 45.5 (-110/-110) | 46.5 (-110/-110) | 45.5 (-115/105) |
| Bears vs. Buccaneers | 44 (-110/-110) | 43.5 (-110/-110) | 40.5 (-115/-105) | 40.5 (-115/-105) |
| Packers vs. Falcons | 41 (-110/-110) | 41.5 (-110/-110) | 40.5 (-110/-110) | 40.5 (-105/-115) |
| Colts vs. Texans | 41 (-110/-110) | 40.5 (-105/-115) | 39.5 (-110/-110) | 39.5 (-105/-115) |
| Chiefs vs. Jaguars | 50 (-110/-110) | 51.5 (-110/-110) | 51.5 (-105/-115) | 51.5 (-105/-115) |
| Chargers vs. Titans | 46.5 (-110/-110) | 45.5 (-105/-115) | 45.5 (-105/-115) | 45.5 (-105/-115) |
| Raiders vs. Bills | 47.5 (-110/-110) | 48 (-110/-110) | 47 (-105/-115) | 47.5 (-105/-115) |
| Seahawks vs. Lions | 51.5 (-110/-110) | 50.5 (-115/-105) | 47.5 (-110/-110) | 47.5 (-105/-115) |
| Giants vs. Cardinals | 38 (-110/-110) | 38.5 (-105/-115) | 39.5 (-118/-104) | 39.5 (-118/-104) |
| 49ers vs. Rams | 42.5 (-110/-110) | 42.5 (-110/-110) | 44.5 (-115/-105) | 45.5 (-110/-110) |
| Jets vs. Cowboys | 46.5 (-110/-110) | 45.5 (-105/-115) | 38.5 (-105/-115) | 38.5 (-105/-115) |
| Commanders vs. Broncos | 41.5 (-110/-110) | 40 (-110/-110) | 39.5 (-106/-114) | 38.5 (-115/-105) |
| Dolphins vs. Patriots | 45 (-110/-110) | 45.5 (-115/-105) | 46.5 (-110/-110) | 46.5 (-105/-115) |
| Saints vs. Panthers | 42.5 (-110/-110) | 40.5 (-110/-110) | 40 (-110/-110) | 39.5 (-115/-105) |
| Browns vs. Steelers | 43.5 (-110/-110) | 42.5 (-105/-115) | 38.5 (-110/-110) | 38.5 (-106/-114) |
The outcomes of Week 1 matches greatly influenced the betting odds for Week 2, evident in the fluctuations of totals leading up to the games.
Travis Kelce not playing in Thursday Night Football versus the Detroit Lions and Kadarius Toney’s underwhelming performance as a wide receiver led to the total for the Chiefs-Jaguars game at FanDuel decreasing from 52.5 to 50.5. However, as Sunday’s matchup approaches, the total has gradually increased back to 51.5.
The Browns-Steelers total has continued to decrease since opening at 42.5 at FanDuel, now down to 38.5. This drop is a result of the Steelers’ offense, led by Kenny Pickett, struggling to gain yardage in Week 1 against the San Francisco 49ers.
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