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The Jacksonville Jaguars and quarterback Trevor Lawrence are a home favorite over the Cincinnati Bengals in the NFL Week 13 odds & betting lines.
Trevor Lawrence of the Jacksonville Jaguars runs onto the field before the game against the Houston Texans. Photo by Mike Carlson via Getty Images/AFP.

Our review of the NFL Week 13 odds and betting lines from top NFL betting sites begins with an NFC clash between the Seattle Seahawks and Dallas Cowboys, and wraps up with a Monday Night Football game between the Cincinnati Bengals and Jacksonville Jaguars.

In Week 13, the highly anticipated game between the San Francisco 49ers and the Philadelphia Eagles at Lincoln Financial Field will have a major impact on both Super Bowl and NFL MVP odds in the NFC.

The Monday Night Football game between the Cincinnati Bengals and Jacksonville Jaguars would have had significant AFC implications, but with Bengals quarterback Joe Burrow out for the season with a wrist injury, the Jags are now heavy favorites.

Instead, in this AFC matchup, we have two 6-5 teams with intriguing playoff implications. The Denver Broncos are taking on the Houston Texans, as Houston aims to recover from a Week 13 loss and Denver looks to extend their winning streak to six games.

Furthermore, two more NFC games will showcase potential playoff contenders facing off in high-stakes matchups. The week kicks off with the Seattle Seahawks taking on the Dallas Cowboys on Thursday Night Football, followed by the New Orleans Saints hosting the Detroit Lions in a crucial game for both teams coming off losses in Week 12.

Take a deeper dive into the NFL Week 13 odds from top sports betting sites.

NFL Week 13 odds and lines

It is beneficial to place bets on early NFL odds in order to try and outperform the final betting line. Waiting until closer to kickoff makes it harder to find advantages and get the best possible odds on most bets.

It is crucial to begin monitoring the NFL opening odds early each week in order to increase the chances of long-term success. Taking a proactive approach is key.

Best NFL Week 13 spreads

(Odds via Caesars)

GameSpread (Nov. 28)Opening spread (Nov. 22)
Seahawks vs. CowboysCowboys -9Cowboys -7
Colts vs. TitansTitans +2Titans +1
Chargers vs. PatriotsPatriots +6Patriots +4.5
Lions vs. SaintsSaints +4Saints +3
Falcons vs. JetsJets +2.5Jets +1.5
Cardinals vs. SteelersSteelers -5.5Steelers -3
Dolphins vs. CommandersCommanders +9.5Commanders +7
Broncos vs. TexansTexans -3.5Texans -3
Panthers vs. BuccaneersBuccaneers -5.5Buccaneers -5.5
Browns vs. RamsRams -4Rams -1
49ers vs. EaglesEagles +2.5Eagles -1.5
Chiefs vs. PackersPackers +6.5Packers +7
Bengals vs. JaguarsJaguars -8.5Jaguars -7

Six home underdogs remain from the Week 13 opening odds, with only the Cowboys, Jaguars, and Miami Dolphins favored by more than a touchdown. There are not many lopsided spreads in this week’s matchups.

Furthermore, out of the remaining games, only three have a margin of a field goal or less, with one of them being the highly anticipated NFC matchup between the 49ers and Eagles. This is a decrease from the seven close games initially predicted.

Best NFL Week 13 moneylines

(Odds via DraftKings)

GameMoneyline (Nov. 28)Opening moneyline (Nov. 22)
Seahawks vs. CowboysCowboys -455Cowboys -285
Colts vs. TitansTitans +114Titans -110
Chargers vs. PatriotsPatriots +210Patriots +160
Lions vs. SaintsSaints +164Saints +130
Falcons vs. JetsJets +124Jets +105
Cardinals vs. SteelersSteelers -238Steelers -180
Dolphins vs. CommandersCommanders +350Commanders +240
Broncos vs. TexansTexans -192Texans -155
Panthers vs. BuccaneersBuccaneers -238Buccaneers -258
Browns vs. RamsRams -175Rams -120
49ers vs. EaglesEagles +130Eagles -125
Chiefs vs. PackersPackers +230Packers +240
Bengals vs. JaguarsJaguars -380Jaguars -278

The Cowboys, Dolphins, Jaguars, and Chiefs are the top favorites in Week 13. Furthermore, the Tennessee Titans and Philadelphia Eagles have switched from being favored at home to being underdogs, with the lines shifting even more in favor of the Pittsburgh Steelers and Los Angeles Rams.

Best NFL Week 13 Over/Unders

(Odds via bet365)

GameOver/Under Nov. 28Opening Over/Under Nov. 22
Seahawks vs. Cowboys46 (-110/-110)45.5 (-110/-110)
Colts vs. Titans43 (-110/-110)41 (-110/-110)
Chargers vs. Patriots40.5 (-110/-110)42.5 (-110/-110)
Lions vs. Saints44.5 (-110/-110)44.5 (-110/-110)
Falcons vs. Jets36.5 (-110/-110)36.5 (-110/-110)
Cardinals vs. Steelers40 (-110/-110)39.5 (-110/-110)
Dolphins vs. Commanders50 (-110/-110)49 (-110/-110)
Broncos vs. Texans46.5 (-110/-110)44.5 (-110/-110)
Panthers vs. Buccaneers37 (-110/-110)39 (-110/-110)
Browns vs. Rams39.5 (-110/-110)39 (-110/-110)
49ers vs. Eagles46.5 (-110/-110)45.5 (-110/-110)
Chiefs vs. Packers42 (-110/-110)41.5 (-110/-110)
Bengals vs. Jaguars38.5 (-110/-110)41 (-110/-110)

In Week 13 odds, there are four games with totals still under 40 points and five games with totals above the key range of 43-44. Over the past month, there have been few totals approaching or exceeding 50 points due to quarterback injuries and subpar performances from signal-callers.

NFL betting odds pages

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