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Jimmy Garoppolo #10 of the Las Vegas Raiders throws the ball as we look at our Patriots-Raiders predictions.
Jimmy Garoppolo of the Las Vegas Raiders throws the ball during the fourth quarter against the Green Bay Packers at Allegiant Stadium on October 09, 2026 in Las Vegas, Nevada. Photo by Candice Ward/Getty Images via AFP.

In Week 6, the New England Patriots will be facing off against the Las Vegas Raiders at Allegiant Stadium. One of our key predictions for the Patriots vs. Raiders matchup is that the New England defense will perform well on the road. Our NFL picks are determined by the odds offered by top sports betting apps.

The New England Patriots suffered a devastating 34-0 loss last week, marking their second consecutive lopsided defeat. With a record of 1-4, they are now in contention for finishing the regular season with the NFL’s worst record.

Conversely, the Las Vegas Raiders (2-3) broke a three-game losing streak with a 17-13 victory over the Green Bay Packers on Monday Night Football, thanks to a late interception that secured the win.

Can the Raiders continue New England’s struggles, or will the Patriots get back on track in our Week 6 NFL best bets?

Here is our Patriots vs. Raiders prediction and NFL picks for Week 6, with odds from top NFL betting sites and confidence ratings on a 1-to-5-star scale.

Patriots vs. Raiders prediction

Patriots +3 (-115 via BetMGM) ⭐⭐⭐⭐

The New England Patriots are currently struggling with a 1-4 record after being outscored 72-3 in their last two games. Despite this rough patch, it’s worth acknowledging the tough competition they’ve faced, with opponents like Philly, Miami, Dallas, and New Orleans having a combined record of 16-5. Additionally, the Jets have a strong defense, making the Patriots’ recent losses more understandable.

A trip to Las Vegas provides a refreshing change of pace for New England as they aim to regain their momentum. Jones will have plenty of motivation to perform well, as he may be playing to secure his starting position after being replaced in the team’s previous two games. The Patriots’ running game, which was neglected in favor of passing due to large point differentials in recent games, should provide Jones with better support in this matchup.

Nevertheless, New England’s greatest strength in this matchup lies in their defense, which is ranked eighth in total yards allowed per game and sixth against the pass. The Patriots’ pass rush is expected to put pressure on the Vegas offensive line, which has given up 15 sacks in their last three games. This could lead to Jimmy Garoppolo, who leads the league in interceptions, making hasty decisions and errors.

Las Vegas has yet to score over 20 points in a game this season. The Raiders are facing a quick turnaround after a close victory against Green Bay on Monday night. Additionally, they have a poor record of 6-16 against the spread in their last 22 games as favorites.

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Patriots vs. Raiders best odds

BetMGM +3 (-115)

DraftKingsFanDuelBetMGMCaesarsbet365
+3+2.5+3+2.5+2.5
-118-102-115-105-105

Out of all the games on the upcoming NFL betting card, this particular match-up offers the most potential for finding the best odds by shopping around. Some of the top sports betting apps have lowered the point spread to less than a field goal with better odds for the Patriots, while others are still offering New England +3 with higher vig.

As of now, BetMGM is the top pick for New England point spread supporters, offering a +3 with the Patriots at just a five-cent premium. Getting a full three-point advantage with the underdog is highly advantageous in a game with a low total.

Patriots vs. Raiders odds 

Patriots vs. Raiders odds analysis

FanDuel originally had the Raiders as slight 1.5-point favorites, but changed the line to Las Vegas being 3.5-point favorites after the Raiders defeated Green Bay and the Patriots suffered another blowout loss. The line quickly shifted to New England being +3, and by Friday morning, some top sports betting sites had the line even lower than that.

The Under has gained strong backing in light of New England’s shutout by the Saints and the Raiders’ continued offensive struggles against the Packers. As of now, the consensus total is 41, a few points lower than the initial line.

Patriots vs. Raiders game info

  • When: Sunday, Oct. 15 at 4:05 p.m. ET
  • Where: Allegiant Stadium, Las Vegas, NV
  • How to watch: FOX
  • Weather: Indoors

Prediction for the Patriots-Raiders game was made on Friday at 7:54 a.m. ET.

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