Christian McCaffrey NFL Player Props, Odds for Thanksgiving: Predictions for 49ers vs. Seahawks

Christian McCaffrey scored two touchdowns in both games against the Seahawks for the 49ers in 2023. Now, we analyze if he will have another strong performance on Thanksgiving with our Christian McCaffrey player prop predictions using the top NFL odds available.
The Thanksgiving tripleheader culminates in an electrifying showdown as the 7-3 San Francisco 49ers face off against the 6-4 Seattle Seahawks at Lumen Field. This highly anticipated NFC West matchup promises an intense battle between divisional rivals that could have a major impact on the standings. With both teams vying for a crucial victory, the clash at Lumen Field adds an extra layer of excitement to the holiday festivities as they compete for divisional supremacy.
Last week, San Francisco secured a solid 27-14 victory over the Tampa Bay Buccaneers in their home game. Brock Purdy shined with an impressive performance, throwing for 333 yards and three touchdowns. Additionally, Christian McCaffrey rushed 21 times for 78 yards, while Brandon Aiyuk made five catches for 156 yards and a touchdown.
Meanwhile, Seattle suffered a devastating one-point loss to the Los Angeles Rams at SoFi Stadium in Week 11. The Seahawks are heading into this game with worries about quarterback Geno Smith’s elbow following a quick turnaround.
Here are our top Christian McCaffrey player props for the Week 12 Thanksgiving matchup between the San Francisco 49ers and Seattle Seahawks, along with our NFL Thanksgiving predictions, 49ers vs. Seahawks predictions, 49ers vs. Seahawks prop bets, and Brock Purdy player props. Odds are provided by our top NFL betting sites, and pick confidence is rated on a 1-to-5-star scale.
Christian McCaffrey NFL player prop predictions for Thanksgiving
- Christian McCaffrey Over 74.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐
- Christian McCaffrey Over 32.5 receiving yards (-114 via FanDuel) ⭐⭐⭐
- Christian McCaffrey to score two-plus touchdowns (+220 via Caesars) ⭐⭐⭐
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Christian McCaffrey player props for Thanksgiving
Christian McCaffrey Over 74.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐
Last season, CMC had a field day against the Seattle defense when he played against them with the Niners. In both the regular season and postseason games, McCaffrey ran for a total of 227 yards against the Seahawks, with 108 yards gained at Lumen Field in a Thursday night matchup in December.
McCaffrey leads the league in rushing yards this season with 825 yards, averaging 82.5 yards per game. Coach Shanahan plans to focus on Seattle’s run defense, which is more vulnerable than their secondary.
During a shortened week, expect the 49ers’ offense to have over 40 rushing attempts, with CMC benefiting from it.
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Christian McCaffrey Over 32.5 receiving yards (-114 via FanDuel) ⭐⭐⭐
Christian McCaffrey has accumulated 364 receiving yards on 43 catches this season, averaging 36.4 yards per game. Next Gen Stats show that CMC leads all running backs with 25 targets, 20 receptions, and 177 yards when he lines up wide or in the slot. He is a versatile threat on offense, able to make an impact from any position on the field.
The 49ers have a perfect 11-0 record when McCaffrey has 20 or more scrimmage touches since he joined the team last season, including postseason games. On the other hand, they are 8-5 when McCaffrey has fewer than 20 touches, and all three of their losses this season came in those games.
McCaffrey has surpassed 1,189 scrimmage yards in five out of the ten games he has played so far this year.
Christian McCaffrey 2+ touchdowns (+220 via Caesars) ⭐⭐⭐
McCaffrey leads the NFL in touchdowns this season with a total of 14, consisting of nine rushing touchdowns and five receiving touchdowns.
He has scored multiple touchdowns in three games, and only failed to find the endzone in one game. Due to his consistent success in scoring, his odds of being an anytime touchdown scorer are low, with the best price being -200.
Nevertheless, this Seattle defense may provide the opportunity for a standout performance, particularly if the 49ers are able to establish their running game from the start.
The player props for Christian McCaffrey on Thanksgiving Day were released on 11/23/2023 at 5 a.m. ET.
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