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D.J. Wonnum #98 of the Minnesota Vikings sacks Jordan Love #10 of the Green Bay Packers as we look at the best Week 17 NFL odds.
D.J. Wonnum #98 of the Minnesota Vikings sacks Jordan Love #10 of the Green Bay Packers in the first quarter of a game at Lambeau Field on October 29, 2026 in Green Bay, Wisconsin. Photo by Michael Reaves/Getty Images via AFP.

As Week 17 of the NFL regular season unfolds, playoff seedings are beginning to take shape. We can get an early glimpse of what to expect by examining the opening odds and betting lines for the upcoming games from top NFL betting sites.

Due to no games being scheduled on New Year’s Day, the Week 17 NFL games are spread out between Thursday, Saturday, and Sunday.

The AFC matchup on Thursday night features the New York Jets taking on the Cleveland Browns, who are making a strong push towards the postseason. On Saturday, the Dallas Cowboys will host the Detroit Lions in a game that could potentially impact Super Bowl odds. Despite being played on a Saturday, the NFL is treating this game as the final Monday Night Football of the year.

On Sunday, there is a packed 14-game schedule, with one of the most anticipated matchups being the Miami Dolphins taking on the Baltimore Ravens in the AFC. The final Sunday Night Football game of the season will see the Green Bay Packers facing off against the Minnesota Vikings in a crucial NFC North showdown.

Let’s take a closer look at the NFL Week 17 odds offered by our top sports betting sites.

NFL Week 17 odds and lines

Betting early on NFL odds gives you an advantage in trying to beat the closing line. Waiting until kickoff to make your picks makes it more challenging to find edges and get the best number on side or total wagers.

It is crucial to begin tracking the NFL opening odds weekly at the earliest opportunity. Taking a proactive approach is key to achieving sustained success in the long run.

Best NFL Week 17 spreads

(Odds via bet365)

GameSpread
Jets vs. BrownsBrowns -5.5
Lions vs. CowboysCowboys -5.5
Cardinals vs. EaglesEagles -10
Falcons vs. BearsBears -3
Panthers vs. JaguarsJaguars -9
Rams vs. GiantsGiants +6
Raiders vs. ColtsColts -3
Dolphins vs. RavensRavens -3
Patriots vs. BillsBills -13.5
Saints vs. BuccaneersBuccaneers -2
49ers vs. CommandersCommanders +13.5
Titans vs. TexansTexans -4.5
Steelers vs. SeahawksSeahawks -3.5
Bengals vs. ChiefsChiefs -7.5
Chargers vs. BroncosBroncos -6.5
Packers vs. VikingsVikings -2

In Week 17, it appears that home teams will dominate, with 14 out of 16 games featuring a home favorite. Additionally, five games have a betting line of a field goal or less as we preview the upcoming week.

There are four games with spreads greater than seven points, three of which are over 10 points. The Bills and 49ers have the largest spreads of the week, at 13.5 points. San Francisco is one of only two road favorites in the lineup.

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Best NFL Week 17 moneylines

(Odds via FanDuel)

GameMoneyline
Jets vs. BrownsBrowns -255
Lions vs. CowboysCowboys -235
Dolphins vs. RavensRavens -156
Patriots vs. BillsBills -720
Falcons vs. BearsBears -156
Titans vs. TexansTexans -230
Raiders vs. ColtsColts -174
Rams vs. GiantsGiants +215
49ers vs. CommandersCommanders +610
Panthers vs. JaguarsJaguars -370
Cardinals vs. EaglesEagles -500
Saints vs. BuccaneersBuccaneers -134
Steelers vs. SeahawksSeahawks -200
Bengals vs. ChiefsChiefs -290
Chargers vs. BroncosBroncos -280
Packers vs. VikingsVikings -120

The Bills, 49ers, and Eagles are the top favorites to kick off Week 17, which is not surprising given that they are Super Bowl contenders with star quarterbacks who are in good health and highly favored in the NFL MVP race.

The closest margin of the week is the Vikings -120 facing off against the Packers on Sunday Night Football.

Best NFL Week 17 Over/Unders

(Odds from DraftKings)

GameOver/Under
Jets vs. Browns35.5 (-110/-110)
Lions vs. Cowboys50.5 (-110/-110)
49ers vs. Commanders48 (-110/-110)
Panthers vs. Jaguars39.5 (-110/-110)
Falcons vs. Bears37.5 (-110/-110)
Rams vs. Giants41 (-110/-110)
Raiders vs. Colts44 (-110/-110)
Patriots vs. Bills40 (-110/-110)
Dolphins vs. Ravens46.5 (-110/-110)
Cardinals vs. Eagles47.5 (-110/-110)
Saints vs. Buccaneers41.5 (-110/-110)
Titans vs. Texans43 (-110/-110)
Steelers vs. Seahawks41 (-110/-110)
Chargers vs. Broncos38 (-110/-110)
Bengals vs. Chiefs45.5 (-110/-110)
Packers vs. Vikings43.5 (-110/-110)

This week is shaping up to be another with low scores anticipated due to backup QBs starting in various games and a rise in injuries. The highest scoring game is predicted to be the Lions-Cowboys matchup with a line of 50.5 points, while four other games have lines set below 40 points.

There are three games with numbers between 43 and 44.

NFL betting odds pages

Here are our best NFL betting sites:

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