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Uruguay forward Darwin Nunez celebrates his goal as we look at our USA vs. Uruguay picks and predictions
Uruguay forward Darwin Nunez celebrates his goal past Bolivia goalkeeper Guillermo Viscarra. Photo Credit: Vincent Carchietta-USA TODAY Sports.

The hosts of the Copa America 2026 face a significant challenge as they aim to secure a spot in the quarter-finals of the tournament. Here are our predictions for Monday’s USA vs. Uruguay match, based on the odds provided by top soccer betting sites.

The fate of the USA in Copa America is within their control, but they have set themselves a significant challenge following their 2-1 loss to Panama on Thursday.

If Gregg Berhalter’s team can defeat Uruguay on Monday, they will secure their spot in the quarterfinals. However, they will need to find a way to contain the top scorers in the tournament in order to do so.

Uruguay scored five goals against Bolivia in their second Group C match, marking their biggest win in over 60 years at the competition. With a total of eight goals in the first two matches, La Celeste has scored more goals at this stage of the tournament than in any of their last four appearances at the Copa America.

Uruguay ranks just below tournament favorites Argentina and Brazil in the Copa America odds, with Darwin Nunez leading the way in the race for top goal scorer.

USA vs. Uruguay predictions for Monday

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USA vs. Uruguay score prediction

Uruguay 3 vs. USA 1

Uruguay has not lost in their last six international matches. In their 5-0 victory over Bolivia on Thursday, five different players found the back of the net. Uruguay managed to have 43 touches inside Bolivia’s box and completed 15 shots from within the penalty area.

Team USA had an equal number of shots inside the box against Bolivia in their first game and scored two goals. The team’s defense has been unreliable, allowing six goals to be scored in their two warm-up matches before the tournament, and two goals against Panama, ranked 43rd in the world. The Americans played most of the match with 10 players after Timothy Weah was sent off just 18 minutes into the game.

Panama’s sending-off helped them maintain possession with an impressive 73%. The US attempted only six shots in that match, their lowest in the competition. Uruguay has been scoring an average of three goals per game in their last four matches and have only conceded once. La Celeste have only lost one of their last ten games and are confident about their upcoming match.

The United States is currently struggling and with +2800 odds at bet365, a $10 bet on Uruguay winning 3-1 would result in a profit of $280. These odds suggest a 3.4% chance of happening.

Bet365 offers the best odds at +2800.

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USA vs. Uruguay anytime goal scorer prediction

Darwin Nunez, Uruguay

The Liverpool striker is currently tied for the top scorer position in the tournament, having scored two goals in two games. Nunez has taken nine shots and is averaging a goal every 87 minutes. He netted a hat-trick in Uruguay’s last friendly against Mexico.

Nunez is the third Uruguayan player in this century to score in both of his first two Copa America matches. Uruguay has attempted 46 crosses in the tournament, providing opportunities for Nunez, who is a key offensive target. The U.S. defense may be vulnerable to his attacking prowess.

The odds at +210 from bet365 provide the highest value, suggesting a 32.3% chance that Nunez will score again. A $10 bet on Nunez scoring will earn a profit of $21 if successful.

Top odds: +210 at bet365

USA vs. Uruguay best bet

Both teams score and no draw

Uruguay’s offense has been on fire in their recent matches, netting 12 goals in just three games. Meanwhile, the Stars and Stripes have managed to score in their last six outings, but have only kept two clean sheets in their last eight matches.

In order to secure their spot in the knockout stage, the United States must secure a victory by taking on Uruguay’s defense. Uruguay has only been scored on once in 10 matches and has the ability to capitalize on any high press tactics employed by the U.S. in their pursuit of a goal.

DraftKings has odds of +195, which suggest a 33.9% probability of winning. A $10 bet would result in a profit of $19.50 if successful.

Top odds: +195 at DraftKings

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USA vs. Uruguay game info

  • When: Monday, July 1, 9 p.m. ET
  • Where: Arrowhead Stadium, Kansas City, MO
  • How to watch: FS1, Fubo
  • Favorite: USA (+155 via DraftKings)

Predictions for the USA-Uruguay match were made on Saturday at 12:19 p.m. ET.

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