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Deebo Samuel of the San Francisco 49ers celebrates a touchdown against the Chicago Bears as we look at our best 49ers-Eagles prediction.
Deebo Samuel of the San Francisco 49ers celebrates a touchdown against the Chicago Bears. Photo by Michael Reaves/Getty Images via AFP.

In a highly anticipated matchup, the Philadelphia Eagles will host the San Francisco 49ers in a Week 13 showdown between the NFC’s top teams. We provide our top prediction for the 49ers vs. Eagles game based on the latest NFL odds from leading sportsbooks for this rematch of the 2023 NFC Championship.

As of this week, the San Francisco 49ers are one of three NFC teams with an 8-3 record and one of five teams in the NFL on a winning streak of three games or more. On Thanksgiving, the 49ers defeated the Seattle Seahawks by 18 points, extending their divisional winning streak to 10 games, the longest current streak in the league.

In the meantime, the Philadelphia Eagles have accomplished something extraordinary by becoming the first team since the 1991 Buffalo Bills to lose a Super Bowl and then start the next season with a record of 9-1 or better. With their current 10-1 record, much of their success can be credited to Jalen Hurts’ outstanding performance, where he achieved his first career five-touchdown game.

Here are our top 49ers vs. Eagles NFL player props, along with our expert prediction and NFL picks. Odds are from our recommended NFL betting sites, and pick confidence is rated on a 1-to-5-star scale.

Make sure to check out our Jalen Hurts, Brock Purdy, Christian McCaffrey, and A.J. Brown NFL player props for some exciting action in the game.

49ers vs. Eagles prediction

49ers first-half moneyline (-125 via Caesars, bet365) ⭐⭐⭐

This game has the potential to become a historical matchup from a point-spread standpoint. According to BetMGM’s John Ewing, only three teams with odds of 10-1 or better have been home underdogs since 2004. However, in two of those cases, the underdog had backup quarterbacks starting because the games took place in Week 17.

Therefore, our top sports betting apps are indicating their belief that San Francisco is the stronger team and will likely dominate Philadelphia, especially considering their strong start to the season. Rather than placing a bet on the 49ers for the entire game, we recommend focusing on the first-half moneyline due to the Eagles’ recent performance in early quarters.

$1,000 First Bet on Caesars

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Philadelphia is currently on a five-game winning streak, which is tied with the Denver Broncos for the longest active streak. The team has been successful in the second half and overtime, out-scoring opponents 79-30 in the last four games. Despite trailing at halftime in four consecutive games, Philadelphia has managed to come back and win all five games this season in which they were trailing at halftime.

During the first 30 minutes of games this season, Hurts is ranked 15th in QBR, tied for 17th in passing touchdowns, and 19th in yards per attempt. However, in the second halves and overtime periods of games, Hurts improves to third in QBR, tied for second in passing touchdowns, and fourth in yards per attempt.

The Eagles have a record of 14-22 when Lane Johnson is not playing, so his injury is a concern this week despite their recent win. On the other hand, San Francisco is currently at its healthiest point this season, with the second-best point differential in the NFL at +140. The team’s previous struggles in Weeks 6-8 were largely due to injuries to key players like Deebo Samuel and Trent Williams. With these players back in action, quarterback Brock Purdy has been performing well, completing 75.3% of his passes with a 7-1 TD-INT ratio over the last three games.

According to Sharp Football Analysis, the 49ers defense is rated as a three-star play, allowing a league-best 9.5% of opponents’ possessions to end in a touchdown in road games. If the weather forecast improves, this could be upgraded to a more confident four-star play. This is based on Purdy’s worst game this season being on the road in a soaking rain at the Cleveland Browns, where he struggled with completion percentage, yards per attempt, and QBR.

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49ers vs. Eagles best odds

Caesars, bet365 (-125)

DraftKingsFanDuelBetMGMCaesarsbet365
-130-128N/A-125-125

Those betting on the 49ers moneyline in the first half may want to consider placing their bets at Caesars or bet365 for the best value. The odds can go as high as -130 at DraftKings. Caesars and DraftKings both offer a -0.5 point spread, while FanDuel has a slightly higher -1.5 spread. However, we recommend going with the moneyline odds for added insurance, as bets will be voided and returned if the 49ers and Eagles are tied at halftime.

We are also not considering betting against Philadelphia on the full-game moneyline, as they have won all 11 of their last games at Lincoln Financial Field against teams with a winning record.

49ers vs. Eagles odds

49ers vs. Eagles odds analysis

The point spread for this matchup varies among the top sports betting apps. BetMGM offers the lowest line at San Francisco -1.5, but with a -130 juice for the favorite. DraftKings has the highest line at -3 for the 49ers. Other competitors are around -2.5, with FanDuel briefly hitting -3 before dropping back down. The Eagles are a popular underdog, receiving 80% of early point spread bets.

Caesars is the lone sportsbook with a total of 45.5, with other top sports betting sites at 46.5. DraftKings started at 46 and has fluctuated between 46.5 and 47. There is equal action on the total at all top sportsbooks, and the Eagles have the longest current Over streak in the league at four games.

49ers vs. Eagles game info

  • When: Sunday, Dec. 3 at 4:25 p.m. ET
  • Where: Lincoln Financial Field, Philadelphia, PA
  • How to watch: FOX
  • Weather: 54 degrees, 52% chance of precipitation, wind 9 mph NNE

Prediction for the 49ers vs Eagles game on November 29, 2023, was made at 4:01 p.m. Eastern Time.

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