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NFL best bets
NFL best bets

Check out our top NFL picks for Thursday Night Football as the New York Giants take on the San Francisco 49ers. Our experts have compiled their best predictions to help you make the most of your bets on the top NFL betting sites.

The San Francisco 49ers are set to host the New York Giants as 10.5-point favorites in a highly anticipated matchup to kick off Week 3 of the NFL season on Thursday Night Football. Our top sports betting apps and the betting public are eagerly anticipating this lopsided game.

To get you off to a strong start with your NFL Week 3 predictions, here are our top NFL bets and picks for Thursday Night Football. Our selections are based on odds from leading NFL betting sites, with pick confidence rated on a 1-to-5-star scale.

NFL best bets for Thursday Night Football: Giants vs. 49ers

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NFL predictions for Thursday Night Football

49ers -9.5 (-110 via FanDuelCaesars) ⭐⭐⭐

When running back Saquon Barkley was healthy and playing, the Giants had an impressive plus-40.1 offensive EPA, averaged 5.4 yards per play, and 4.7 yards per rush over the last five seasons leading up to 2023-24. However, in games where Barkley was not available, those numbers dropped significantly to a minus-126.9 offensive EPA, 5.0 yards per play, and 4.2 yards per rush.

During the second half against the Arizona Cardinals, Giants QB Daniel Jones made history. However, it is unrealistic to rely solely on him again with a one-dimensional offense if they hope to compete against the explosive 49ers. Niners running back Christian McCaffrey has scored a touchdown in 11 consecutive games, including playoffs. QB Brock Purdy’s streak of six games with two or more passing touchdowns and a passer rating of 95.0 or better was broken in Week 2, but he still managed an impressive 93.1 passer rating and played without any turnovers.

The outcome of Thursday’s game in San Francisco will depend on the margin of victory. We feel confident that the 49ers will win by less than ten points against the injured Giants.

Allen Byron predicts that the Giants will face off against the 49ers.

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Darius Slayton & Isaiah Hodgins each Over 39.5 receiving yards (+425 via Caesars) ⭐⭐⭐⭐

In his first game of the season, Giants quarterback Daniel Jones threw for only 104 yards, and no receiver had more than 36 yards. But in the following game, Jones bounced back with 321 passing yards. Four Giants receivers, including Darius Slayton and Isaiah Hodgins, had more than this yardage.

Hodgins surpassed the threshold in 5 out of 10 games last season, with 3 of those occurrences happening in his last 5 games. He gained 40 receiving yards against the Cardinals. In contrast, Slayton exceeded the threshold in 8 out of 10 games in 2022 and recorded 62 yards in the game against Arizona.

In each of their games this season, San Francisco has permitted a minimum of two receivers to amass over 40 yards, with three players accomplishing this against the 49ers’ secondary in their most recent game.

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Player props for the Giants vs. 49ers game created by Rod Villagomez.

Christian McCaffrey Over 79.5 rushing yards (-113 via FanDuel) ⭐⭐⭐⭐

Why has McCaffrey been unable to achieve his third consecutive 100-yard rushing game to start the season? The Giants allowed James Conner to rush for 106 yards last week, with an average of over four yards per carry against them.

McCaffrey, who was on the field for every play in Week 2, is anticipated to have a similar workload on Thursday. Additionally, it is expected that the 49ers will maintain a lead for the duration of the game. This could be worrisome for some, as there is a concern that if the 49ers build a substantial lead, McCaffrey may be replaced.

If the 49ers take the lead, it will likely be thanks to McCaffrey’s strong performance. It’s a good idea to bet on this outcome, and you may also want to consider wagering on him exceeding 100 yards rushing, which has odds of +200 on DraftKings.

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Phil Wood created player props for Christian McCaffrey.

Brock Purdy longest completion Under 35.5 (-115 via BetMGM) ⭐⭐⭐⭐

In his first two games, Purdy completed 36 passes, the longest being a 31-yard connection with Jauan Jennings in Week 2 against the Los Angeles Rams. His second-longest pass was a 23-yard completion to Brandon Aiyuk in Week 1. Purdy has only completed three regular-season passes that have exceeded this distance throughout his career.

In 2023, the Giants have only allowed one reception for over 34 yards, which happened when Cowboys receiver CeeDee Lamb caught a 20-yard pass from Prescott and added 29 more yards in Week 1. In contrast, in 2022, the Giants gave up an average of 10.9 yards per completion and only allowed three passes of at least 36 yards.

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Rod Villagomez created player props for Brock Purdy.

Giants vs. 49ers anytime touchdown scorer prediction: Kyle Juszczyk, 49ers, FB (+1100 via DraftKings⭐⭐

During Week 2, fullback Kyle Juszczyk was the only non-McCaffrey 49ers back to play, appearing in 62% of offensive snaps. Despite not carrying the ball in 2023, Juszczyk has consistently scored at least two touchdowns in each of the last three seasons with San Francisco, including a high of six in 2020. He has received 20 or more targets in each of the last nine seasons, displaying his versatility, which could be beneficial near the goal line in an upcoming game that many expect to be an easy win for San Francisco. DraftKings is offering appealing +1100 odds, while Caesars has the lowest market odds at +700.

Evans Santiago predicts a touchdown scorer in the Giants vs. 49ers game.

Daniel Jones Over 20.5 pass completions (+105 via DraftKings) ⭐⭐⭐

Jones is expected to finish 21.1 passes against the 49ers, slightly exceeding the total of 20.5 pass completions. This provides an advantage due to the favorable odds. With this projection, Jones can be placed at -110 to complete more than 20.5 passes, giving an edge over the +105 price offered by DraftKings.

If you are unable to place a +105 bet at DraftKings, you may want to explore the Over 19.5 (-130) option at BetRivers, even though it has higher juice. This option actually offers higher expected value compared to taking the Over 20.5 (-102) at FanDuel.

Perry Odelia releases NFL player props for Week 3.

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