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Brock Purdy of the San Francisco 49ers looks to pass as part of our Week 11 Buccaneers vs. 49ers NFL predictions
Brock Purdy of the San Francisco 49ers looks to pass during the second quarter against the Jacksonville Jaguars at EverBank Stadium on November 12, 2026 in Jacksonville, Florida. Photo by Mike Carlson/Getty Images/AFP

Tampa Bay and San Francisco are both aiming for their second consecutive victory, with quarterback Brock Purdy being the focal point of one of our top player props for the Buccaneers vs. 49ers NFL matchup in Week 11, according to the latest NFL odds.

Last season, the San Francisco 49ers dominated in the only matchup against these teams with a 35-7 victory in Purdy’s NFL debut. Purdy threw two touchdown passes, while running back Christian McCaffrey contributed with both rushing and receiving touchdowns.

The Buccaneers will face a tough challenge against the San Francisco defense, which has only allowed 15.9 points per game (second-best) while also scoring the second-most points per game in the league. Tampa Bay, on the other hand, is averaging 19.8 points per game (17th-best) for the season.

Take a look at our predictions for Week 11 in the NFL, as well as our top bets for the week. We also have player props for the Tampa Bay Buccaneers vs. San Francisco 49ers game, with odds from our recommended NFL betting sites. Our picks are rated on a 1 to 5-star scale based on confidence.

Buccaneers vs. 49ers NFL player props: Week 11

Brock Purdy Over 249.5 passing yards (-115 via Bet365) ⭐⭐⭐⭐

In San Francisco’s Week 10 victory against Jacksonville, Brock Purdy surpassed 400 career pass attempts. He boasts an impressive career completion rate of 68.1 percent on 420 attempts, the highest among quarterbacks with over 400 career passes in NFL history. The Buccaneers have allowed the third most passing yards this season, giving up an average of 266.8 yards per game. Purdy leads the league with a passer rating of 109.9 and averages 258.8 passing yards per game, exceeding expectations.

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Rachaad White Under 44.5 rushing yards (-110 via bet365) ⭐⭐⭐⭐

The Buccaneers currently have an average of 3.06 yards per carry this season, putting them on track for their second consecutive season with the lowest rushing average in the NFL. The last team to have the lowest yards per carry in back-to-back years was the Arizona Cardinals in 2005 and 2006. White has been averaging 47.6 yards per game, exceeding the rushing prop total, but he was limited to under 40 yards by the Eagles and less than 30 rushing yards by the Lions, who are ranked first and second in rushing yards defended. The San Francisco 49ers are third in that ranking.

Mike Evans Over 55.5 receiving yards (-110 via bet365) ⭐⭐⭐

Mike Evans is having a standout season with 737 receiving yards so far, leading the Buccaneers in targets, yards per reception, touchdowns, and receiving yards per game. In the previous game against the Titans, he caught six passes for 143 yards and a touchdown on 10 targets. Although the Bucs’ rushing offense is struggling, they will face a tough test against a strong defense. San Francisco ranks 15th in pass defense, allowing an average of 238.3 yards per game.

Player props for the Buccaneers vs. 49ers game were set on Friday at 12 p.m. Eastern Time.

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