Cowboys vs. 49ers Odds, Picks, Predictions for the Divisional Round: Will Both Offenses Stay Hot?

Dak Prescott of the Dallas Cowboys celebrates a touchdown against the Atlanta Falcons during the second quarter at AT&T Stadium in Arlington, Texas. Photo by Tom Pennington/Getty Images via AFP.

The Dallas Cowboys will visit Levi’s Stadium to face the San Francisco 49ers in the Divisional Round on Sunday. Take a look at our top NFL picks with the best odds for this exciting matchup between Big D and San Fran.

After defeating the Buccaneers, the Cowboys secured their first road playoff victory since the 1992 NFC Championship, breaking an eight-game losing streak. This win marked only their fourth playoff victory in the past 25 seasons. As Dak Prescott aims to even out his playoff record (currently 2-3), head coach Mike McCarthy has now achieved an 11-9 playoff record.

At halftime, San Francisco was behind Seattle, but they turned things around in the second half, outscoring the Seahawks 25-6 to secure their spot in the Divisional Round. The 49ers ended the season with a perfect 7-0 record against their division rivals and come into this game on an impressive 11-game winning streak. Furthermore, San Francisco’s 11 double-digit victories this season lead all teams in the league.

Below is our top pick for the Cowboys vs. 49ers NFL match in the Divisional Round, with odds provided by FanDuel. Our confidence in this pick is rated on a scale from 1 to 5 stars.

Explore our selection of prop picks for the Cowboys vs. 49ers game, same-game parlay picks, as well as prop picks for Christian McCaffrey and Brock Purdy.

Cowboys vs. 49ers Game Info

Sunday, January 22nd at 6:30 p.m. ET, the game will be broadcasted on FOX from Levi’s Stadium in Santa Clara, California. The weather forecast for the game is 55 degrees with a 6% chance of precipitation and 8 mph north winds.

Cowboys vs. 49ers Odds

Cowboys vs. 49ers Odds Analysis

San Francisco started as a 4-point favorite at home but has since dropped to -3.5 at most sportsbooks. The betting activity has been fluctuating throughout the week, with the 49ers currently getting 59% of spread bets as of Sunday afternoon, according to our matchup page.

The total has remained consistent throughout the week, starting at 46 and still available through BetMGM and DraftKings on Saturday morning. However, there has been line movement since then, with Caesars and PointsBet now offering the number at 47 as of Sunday afternoon.

Cowboys vs. 49ers Pick

Cowboys vs. 49ers Over 45.5 (-115 via FanDuel) ⭐⭐⭐

Week 7 marked major milestones for the Cowboys and 49ers, with Dak Prescott making his return from a thumb injury and Christian McCaffrey debuting with his new team. Since then, the Cowboys have been averaging 32.3 points per game, while the 49ers have been averaging 30.3. ESPN Stats & Info reports that they are the only two teams to maintain a 30-plus point average during that time frame.

Since Week 8, San Francisco has been the top team in Offensive Efficiency in the NFL. Additionally, Prescott has thrown the most passing touchdowns (27) since his return. Despite this, we are predicting the Over as a three-star play due to Prescott’s 14 interceptions in that timeframe. This, combined with facing a 49ers team with the best turnover margin (+15), could lead to more scoring opportunities for San Francisco if Prescott gives them short fields.

In his six starts, 49ers quarterback Brock Purdy has faced a formidable pass rush from the Dallas Cowboys, who lead the league in pressure percentage (39%) and rank second in sack percentage (9%) and Pass Rush Win Rate (52%). Despite this challenge, head coach Kyle Shanahan is skilled at quickly opening up his receivers. San Francisco may rank 28th in receptions due to their low-volume passing strategy, but their receivers excel in breaking tackles after the catch, leading the league in this category.

Meanwhile, Prescott excelled in throwing passes over 10 yards downfield against Tampa Bay, completing 9 out of 10 attempts with four touchdowns and a flawless 158.3 passer rating. His knack for making big plays, combined with Tony Pollard’s exceptional abilities, could present challenges for the San Francisco defense. Pollard has averaged the highest yards per touch (6.1) among running backs in the last two seasons and is a great complement to a 49ers defense that struggles against versatile running backs who can exploit their vulnerabilities across the field.

Editor’s note: As of Sunday afternoon, the best odds for the Cowboys-49ers Over 46.5 are -110 at BetMGM.

Cowboys vs. 49ers Best Odds

FanDuel (-115)

DraftKings	FanDuel	BetMGM	Caesars	PointsBet
46	45.5	46	46	46
-110	-115	-110	-110	-110

For those willing to pay a little more (-115 instead of -110) to bet on the Over, FanDuel is the best option. While other sportsbooks have the total set at 46, FanDuel offers an additional half-point of value that could be beneficial, especially if Dallas continues to struggle with their kicking game following Brett Maher’s four missed extra points in the previous game.

The Cowboys-49ers selection was made on January 20, 2025 at 6:26 a.m. Eastern Time.

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Written By:
Allen Byron

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he’s especially euphoric starting with conference tournament time in college basketball. Mike’s a big advocate of “fading the public” and making plays that are contrarian, constantly citing that “there are reasons why they have those big shiny buildings in Las Vegas.” When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He’s tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”