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Cowboys vs. 49ers SGP Odds, Picks, Predictions Divisional Round: Explosive Offenses to Break Through

Lopez Julia

Updated on January 22, 2026 at 9:06 AM EST. Read time: 2 minutes and 47 seconds. Find more information on Twitter and Google News.

Elijah Mitchell #25 of the San Francisco 49ers rushes for a touchdown past Leighton Vander Esch #55 of the Dallas Cowboys during the first quarter in the NFC Wild Card Playoff game at AT&T Stadium on Jan. 16, 2022.
Elijah Mitchell #25 of the San Francisco 49ers rushes for a touchdown past Leighton Vander Esch #55 of the Dallas Cowboys during the first quarter in the NFC Wild Card Playoff game at AT&T Stadium on Jan. 16, 2026. Tom Pennington/Getty Images/AFP

Despite having a rookie seventh-round quarterback, the San Francisco 49ers appear unbeatable as they enter the Divisional Round of the NFL playoffs. Can the Dallas Cowboys put up another impressive playoff performance to make the matchup more compelling? Check out our Cowboys vs. 49ers SGP picks using the top NFL odds.

Last weekend, the Cowboys (13-5) defeated Tom Brady for the first time in his NFL career to move on to the Divisional Round where they will face the red-hot 49ers (14-4).

Questioning the strength of San Francisco after 11 straight wins is a challenging task, but Dallas may have its most well-rounded lineup in recent memory. How will Sunday’s matchup unfold between two of the NFL’s most potent offenses?

Below are our top picks for the Cowboys vs. 49ers NFL game, with odds provided by FanDuel. Pick confidence is rated on a scale of 1 to 5 stars.

Take a look at our predictions for the Cowboys vs. 49ers game, as well as our prop bets and Christian McCaffrey prop picks.

Cowboys vs. 49ers SGP Picks Divisional Round

  • Over 46.5 (-110) ⭐⭐⭐⭐⭐
  • Ezekiel Elliott Under 34.5 rushing yards (-110) ⭐⭐⭐⭐
  • Brandon Aiyuk Over 55.5 receiving yards (-110) ⭐⭐⭐⭐

Odds of +577 are available through FanDuel when combined.

Cowboys vs. 49ers Odds

Take a look at our odds for the Super Bowl and the Super Bowl MVP.

SGP Predictions for Cowboys vs. 49ers

Over 46.5 (-110) ⭐⭐⭐⭐⭐

The Niners were one of only six NFL teams this season to have more than half of their games hit the Over, finishing with a record of 10-8. Dallas games ended with a 9-9 total.

In San Francisco’s home games this season, they have a 6-4 record on the Over. With Brock Purdy at quarterback, they are averaging 34.5 points per game. The Cowboys, led by Dak Prescott, have averaged 26.6 points per game and Prescott is coming off a strong performance. We believe this momentum will continue into another high-scoring game.

FanDuel has the total set at 46.5 with standard -110 odds for the Over bet, which is a slightly better value than DraftKings, who also have the total at 46.5 but with higher -120 odds for the Over bet. If the total moves to 47, this recommendation would drop from a five-star play to four stars.

Ezekiel Elliott Under 34.5 rushing yards (-110) ⭐⭐⭐⭐

Ezekiel Elliott’s between-the-tackles style doesn’t match up well against the 49ers, who have held him to just 37 yards on 21 carries in his last two games. The Niners have the best rush defense in the NFL, allowing less than 80 yards per game, so it will be a challenge for Zeke to find success against them.

Pairing a player prop Under bet with our Over selection can be a smart contrarian strategy to increase the overall odds in our Same Game Parlay (SGP). While we anticipate plenty of scoring in this game, we believe that Ezekiel Elliott may not be the primary source of offense against the strong San Francisco run defense. Both DraftKings and FanDuel have set Elliott’s rushing line at 34.5 yards, with FanDuel offering slightly better odds at -110 compared to -115 on DraftKings.

Brandon Aiyuk Over 55.5 receiving yards (-110) ⭐⭐⭐⭐

In the past few weeks, Niners quarterback Brock Purdy has been spreading the ball around to his talented weapons, but Brandon Aiyuk has been especially impressive with his consistent performances. Aiyuk has been averaging 78.5 receiving yards in the last four games, never dropping below 59 yards in a single game.

Aiyuk’s receiving line at FanDuel is set at 55.5 yards with odds of -110, which is four yards lower than the DraftKings line of 59.5 yards with odds of +115. Despite attempting to target a more aggressive line on Aiyuk’s receiving total at DraftKings to increase the combined odds, the FanDuel parlay still offers better odds at +577 compared to +550. This leg of the parlay decreases to three stars at the DraftKings line of 59.5 yards.

Picks for the Cowboys-49ers game were selected on 01/22/2026 at 1:15 p.m. ET.

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Written By:
Lopez Julia
Since graduating from the University of Missouri in 2016, Lopez Julia has covered the St. Louis Cardinals and Blues hockey as a writer for KMOV in St. Louis. He also co-hosts ‘The Big Show’ on KTGR radio in Columbia, Missouri. The show airs in afternoon drive, weekdays from 4-6 p.m. Brenden has contributed to SBR since 2021, providing insights on NFL, NCAAF, NCAAB, and the NBA. You can download his daily baseball podcast, B-Schaeff Daily, on Spotify or Apple podcasts, and you can find Brenden across social media @bschaeffer12.