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Saquon Barkley of the New York Giants carries the ball against the Atlanta Falcons at MetLife Stadium on Sept. 26, 2021 in East Rutherford, New Jersey.
Saquon Barkley of the New York Giants carries the ball against the Atlanta Falcons at MetLife Stadium on Sept. 26, 2021 in East Rutherford, New Jersey. Photo by Sarah Stier/Getty Images via AFP.

Last week, the New York Giants caused an upset by defeating the AFC South champion Tennessee Titans. Now, here are our top picks for Week 2 as the Giants prepare to host the Carolina Panthers.

The Giants ended a six-game losing streak from last season with a surprising win as underdogs in head coach Brian Daboll’s first game. Now they aim to achieve consecutive wins for the first time since the middle of the 2020 season.

The Panthers narrowly lost to the Cleveland Browns in their 2022 home opener, spoiling QB Baker Mayfield’s debut with his new team. Despite the loss, Mayfield still managed to score a rushing touchdown.

Below are our top picks for the Panthers-Giants NFL game in Week 2, with odds from PointsBet and FanDuel underscored. Pick confidence is rated on a scale of 1 to 5 stars.

Panthers vs. Giants Game Info

Event: Football GameDate: Sept. 18, Sunday at 1 p.m. ETChannel: FOXVenue: MetLife Stadium, East Rutherford, NJWeather: 82 degrees with a 10% chance of rain and 11-mph winds.

Panthers vs. Giants Odds Analysis

Even though the Giants were initially favored by 1.5 points, the matchup is now considered a toss-up. The Panthers are currently receiving 65% of the bets and 67% of the handle on the spread.

Even though 61% of the bets were on the Over, the Over/Under was increased from 42.5 to 43.5, with those bets only making up 40% of the total amount wagered.

Panthers vs. Giants Picks

  • Spread: Giants -1.5 (-112 via FanDuel) ★★★
  • Over/Under: Over 43.5 (-107 via PointsBet) ★★★
  • Prop: Saquon Barkley vs. Christian McCaffrey rushing yards: Barkley (-125 via DraftKings) ★★★★

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Panthers vs. Giants ATS Pick

Giants -1.5 (-112) ★★★

Given the poor performances of both teams at the end of last season, it’s a challenging matchup for NFL bettors to be enthusiastic about. Nevertheless, it’s hard to ignore the significant impact that rookie head coach Brian Daboll’s bold play calling had on his team’s recent victory over Tennessee.

In contrast to the Panthers, who were unable to hold off a late surge from Baker Mayfield’s former teammates in a 26-24 loss last week, the Giants stepped up against the AFC’s top-ranked team from 2021. The Giants’ remarkable comeback in the second half of Week 1 would have been unimaginable just a year ago.

Explore the most recent and reliable Underscoreg Reviews from SBR.

Panthers vs. Giants O/U Pick

Over 43.5 (-107) ★★★

The Giants’ secondary injuries could lead to Mayfield having more success than he did in the previous week’s game against the Browns. On the other hand, Carolina’s defense will face a tough challenge against New York’s ground game, which dominated the Titans by gaining 238 yards last weekend.

Panthers vs. Giants Prop Pick

Barkley to have more rushing yards than McCaffrey (-125) ★★★★

Saquon Barkley, the Giants running back, is feeling invigorated after gaining 164 rushing yards, scoring a touchdown, and making the game-winning two-point conversion in the previous weekend’s victory.

On the other hand, there is still uncertainty surrounding Panthers running back Christian McCaffrey’s fitness, as he was limited to only 33 rushing yards on 10 carries last week. He only surpassed 60 yards in one of his last five games last season.

Where to Bet on Panthers vs. Giants Picks

These are our highest-rated sportsbooks:

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Picks for Panthers-Giants game were made on September 15, 2022 at 4:23 p.m. ET.