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Zach Charbonnet of the Seattle Seahawks runs with the ball as we make our best Eagles vs. Seahawks prop picks.
Zach Charbonnet of the Seattle Seahawks runs with the ball in the game against the Los Angeles Rams during the third quarter at SoFi Stadium in Inglewood, California. Photo by Ronald Martinez/Getty Images via AFP.

We anticipate a challenging matchup between the injury-plagued Seattle Seahawks and the San Francisco 49ers in our Thanksgiving Day NFL parlay predictions, utilizing the top NFL odds available.

On Thanksgiving Day, the NFL will showcase three games, each with a point spread of seven or more. However, the highly anticipated matchup between the Seattle Seahawks and San Francisco 49ers is expected to be the highlight of the day. The Seahawks, with a record of 6-4 and two recent losses, are determined to secure a victory and close the gap with the leading 7-3 49ers in the NFC West. This game is crucial in determining the divisional standings and is sure to be filled with excitement as both teams compete for dominance in the NFC West.

In addition to our NFL Thanksgiving predictions, we have identified props in each game to make the day even more thrilling. These are our top NFL Thanksgiving parlay predictions, with odds from our trusted NFL betting sites and confidence levels rated on a 1-to-5-star scale.

Be sure to check out our NFL player props and top bets for Thanksgiving.

Best NFL Thanksgiving parlay predictions

David Montgomery Over 0.5 rushing touchdowns (-124) ⭐⭐⭐⭐

Once again, the Detroit Lions’ running game was dominant as they faced the tough Chicago Bears defense. Montgomery led the way with 76 rushing yards on 12 carries, including the game-winning touchdown with just 29 seconds remaining in the game.

The Green Bay Packers have struggled with their rush defense this season, ranking fifth in the league for most rushing yards allowed. This is partly due to their tendency to start games slowly, forcing them to play catch-up. Of the 19 touchdowns the Packers have allowed so far, nine have been scored on the ground. On average, they are giving up one rushing touchdown per game when playing away from home.

While Montgomery splits carries with Gibbs, he dominates near the goal line, scoring in all but one of the Lions’ games this season. All of his touchdowns have been rushing, so I’ll take the over 0.5 rushing touchdowns prop on Montgomery at -124 to save 30 cents instead of paying a -150 premium on the anytime touchdown bet.

To learn more about the upcoming Thanksgiving game between the Packers and Lions, check out Allen Byron’s prediction and player props for the matchup.

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Micah Parsons Over 0.5 sacks (-260) ⭐⭐⭐

Parsons, the standout linebacker for the Dallas Cowboys, finished as the runner-up in last year’s NFL Defensive Player of the Year voting after recording a career-best 13.5 sacks. This season, he has already accumulated 10 sacks in just 10 games. In the Cowboys’ recent 33-10 victory against the Carolina Panthers, Parsons added 2.5 sacks to his impressive total, marking the seventh time in nine games that he has successfully brought down an opposing quarterback.

After winning their last two games by a total of 82-27, the Cowboys are once again double-digit favorites this week against the Washington Commanders. Parsons is likely to have numerous chances to increase his stats against a team led by quarterback Sam Howell, who has been sacked at least three times in three consecutive games and four times or more in eight out of 11 games this season.

As of Wednesday morning, Caesars and several other top sports betting sites had not yet posted a sacks prop for Parsons. However, a few shops were offering this line at around -260. I would be willing to pay up to -300 juice to include this in our NFL Thanksgiving Parlay.

Phil Wood delves deeper into the upcoming Commanders vs. Cowboys game with his predictions.

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Seattle Seahawks +8.5 (-145) ⭐⭐⭐⭐⭐

The San Francisco 49ers, who have won their last two games by a total of 61-17, are the favored team in this crucial NFC West matchup against the Seattle Seahawks. Seattle, on the other hand, has lost two of their last three games and is facing multiple key injuries on offense. Running back Kenneth Walker III is expected to sit out Thursday’s game due to an oblique injury, while quarterback Geno Smith is hoping to tough it out despite a triceps bruise.

Rarely do you see the Seattle Seahawks as a touchdown underdog at home, and for good cause. The team seldom experiences significant losses at Lumen Field, with just one defeat by more than one possession in the past two years and only three in the last four seasons.

Despite their dominance in recent years, the 49ers have struggled to win by a large margin on the road against NFC West opponents who are well acquainted with their strategies. San Francisco has only won one of their last 12 division road games by more than one score, and the last time they won in Seattle by more than eight points was all the way back in 2006.

Julia Lopez analyzes the upcoming game between the 49ers and Seahawks, offering her prediction for the outcome.

NFL Thanksgiving parlay: +315 via Caesars

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Parlay picks for NFL Thanksgiving made at 8 a.m. ET on Wednesday.

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