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Keenan Allen of the Los Angeles Chargers celebrates as we share our best Broncos vs. Chargers player props.
Keenan Allen of the Los Angeles Chargers celebrates after scoring a touchdown during the first quarter against the Dallas Cowboys. Photo by Kevork Djansezian/Getty Images via AFP.

The Los Angeles Chargers, who have lost five of their six games this year by a field goal or less, have an exciting chance to upset the Baltimore Ravens at home this week. They are our pick for the NFL upset of Week 12, with the top NFL odds from our recommended sportsbooks.

Apart from the Thursday and Friday games, there are few notable underdogs on the NFL Week 12 betting card. The Kansas City Chiefs vs. Las Vegas Raiders game on Sunday has the highest spread of more than four points.

However, we have pinpointed three lucrative betting chances for Week 12, such as the high-stakes game between the Buffalo Bills and Philadelphia Eagles, as well as the Sunday Night Football showdown between the Baltimore Ravens and Los Angeles Chargers.

Explore our predictions for Week 12 of the NFL, including player props and upset picks, all with odds from top NFL betting sites. Confidence levels are rated on a 1 to 5-star scale.

NFL upset picks: Week 12

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NFL upset predictions

Browns ML vs. Broncos (+115 via bet365⭐⭐⭐

Despite being 7-3, oddsmakers are once again undervaluing the Cleveland Browns as they are considered underdogs for the sixth time in 11 games this season. The absence of starting quarterback Deshaun Watson, who is out for the season with a shoulder injury, is a factor in this lack of respect. However, the majority of Cleveland’s success this year has come with a backup quarterback leading the team. In their last game, rookie Dorian Thompson-Robinson guided the Browns to a late game-winning field goal in his first career start.

In the meantime, the Denver Broncos have continued their impressive midseason resurgence by securing a 21-20 win against the Minnesota Vikings last week. This marked Denver’s fourth consecutive victory following a 1-4 start to the season.

Yet, the Broncos have only won three of their last four games by a margin of two points or less, and their success has been largely due to an unsustainable plus-11 turnover ratio. In their last six games, Russell Wilson and the offense have failed to score more than 24 points.

Cleveland’s strong ground game is expected to give them an advantage against Denver, whose defense is ranked last in the NFL in both rushing yards and yards per attempt allowed.

I prefer using bet365 as they offer the best odds for betting on the Browns, with a price of +115 compared to other sports betting apps which have Cleveland listed at +105. Given the Browns should be favored in this game, I am happy to take any plus-money price available.

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Bills ML vs. Eagles (+150 via bet365) ⭐⭐⭐⭐

The Buffalo Bills, with a record of 6-5, had been struggling with a 2-4 stretch, including losses to the New England Patriots and Denver Broncos. However, they are optimistic that they have turned things around after a convincing 32-6 victory over the New York Jets last week, their first cover in seven games.

In Joe Brady’s first game as the Bills’ new offensive coordinator, Buffalo successfully reduced the turnovers that have been a problem for the team in recent months, only giving the ball away once.

If the Bills can continue to play a mistake-free game on offense, they have the talent to compete with the Philadelphia Eagles. Despite Philadelphia’s impressive 9-1 record and recent win over the Kansas City Chiefs, Jalen Hurts has struggled in their last two games, throwing for only 357 yards.

If not for a few uncharacteristic turnovers and a dropped touchdown pass by Kansas City in the final moments, Philadelphia’s run defense, which allowed 168 yards against the Chiefs on Monday, likely would have resulted in a loss for the Eagles.

The Eagles are facing a challenging situation, hosting a non-conference opponent on a short week after big wins against the Chiefs and Cowboys, with games against the 49ers and Cowboys coming up next.

Buffalo is expected to be the more determined and motivated team in this match, which makes the potential +150 return from a preseason Super Bowl favorite too tempting to ignore.

Chargers ML vs. Ravens (+168 via FanDuel⭐⭐⭐

The 4-6 Los Angeles Chargers are in a crucial moment as they head into Week 12, trailing five other teams in the competition for an AFC wild-card spot. Despite their losing record, the Chargers have been competitive in most of their games this season, with five of their six losses being decided by a field goal or less. This includes their narrow 23-20 loss to the Green Bay Packers last week.

The Baltimore Ravens, with a record of 8-3, continued to lead the AFC North after defeating the Cincinnati Bengals 34-20 last Thursday. This victory marked their fifth win in the last six games. Unfortunately, the Ravens suffered a setback in their Super Bowl aspirations with the loss of star tight end Mark Andrews, who is Lamar Jackson’s go-to target in the passing game.

Andrews’ absence is significant for a Chargers defense that struggles against the pass but holds up well against the run, allowing only four yards per carry. On the other hand, Justin Herbert has been on fire lately, throwing nine touchdowns and only one interception in his last four games. He should have success moving the ball against a shaky Baltimore defense that appeared vulnerable after Joe Burrow’s injury last week. Given the odds, I’m willing to bet on the Chargers finally pulling out a close game in their favor.

Allen Byron is also favoring the home team in his prediction for the Ravens vs. Chargers Sunday Night Football matchup, as they are his favorite team.

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NFL upset predictions were made on November 22, 2023 at 4:15 p.m. Eastern Time.

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