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Sam Howell of the Washington Commanders warms up prior to the game against the Dallas Cowboys as we look at our NFL upset picks for Week 13.
Sam Howell of the Washington Commanders warms up prior to the game against the Dallas Cowboys. Photo by Ron Jenkins/Getty Images/AFP.

As we approach a small NFL schedule on Sunday, we are supporting two teams that have recently changed coaches in our Week 13 NFL upset predictions, using the most favorable NFL odds from our top sports betting apps.

Following Black Friday, the NFL coaching community faced a challenging weekend as the Carolina Panthers and Washington Commanders both made changes to their staffs after disappointing losses. This indicated to their fans that the teams are still determined to salvage their 2023 seasons.

Carolina dismissed head coach Frank Reich, while Washington allowed defensive coordinator Jack Del Rio to depart.

While the two struggling teams look to improve, the Philadelphia Eagles (10-1) are aiming to continue their winning streak as they face off against the San Francisco 49ers (8-3) in a highly-anticipated matchup of NFC powerhouses.

Along with our predictions for NFL Week 13 and player props, here are our top upset picks for the week (odds sourced from our preferred NFL betting sites; confidence level rated on a scale of 1 to 5 stars).

NFL upset picks: Week 13

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NFL upset predictions

Panthers ML vs. Buccaneers (+210 via Bet365) ⭐⭐⭐⭐

After last week’s 17-10 loss to the Tennessee Titans, the Carolina Panthers decided to make changes by firing head coach Frank Reich, as well as their quarterback and running back coaches.

Even at 1-10, the Panthers are showing determination to salvage something from this season by evaluating their decision to draft Bryce Young as their franchise quarterback. The introduction of new leadership could inject some much-needed energy into the struggling team.

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After their bye week, Carolina’s players hit the mental reset button and came back to surprise the Houston Texans with a 15-13 victory, their only win of the season.

I believe they should be able to replicate that success against the Tampa Bay Buccaneers, who have only won one game out of their last seven after starting the season 3-1. Buccaneers quarterback Baker Mayfield is currently dealing with an ankle injury that caused him to briefly exit their Week 12 loss to the Indianapolis Colts.

Tampa Bay’s offense is unlikely to distance themselves from the Panthers in this game, as they have only scored more than 20 points once since the beginning of October.

Check out our Panthers vs. Buccaneers NFL player props for additional information on this game.

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Commanders ML vs. Dolphins (+360 via FanDuel) ⭐⭐⭐

After a humiliating 45-10 loss to the Dallas Cowboys on Thanksgiving Day, the Washington Commanders (4-8) made a leadership change by firing veteran defensive coordinator Jack Del Rio last week.

The defense will be under the leadership of head coach Ron Rivera for the remainder of the season, potentially bringing more accountability to the team’s underperforming players. It’s important to remember that this team put up a strong fight against the defending NFC champion Philadelphia Eagles in two games in 2023. With league passing leader Sam Howell at the helm, the Commanders have the ability to compete with any opponent.

On Black Friday, the Miami Dolphins secured a 34-13 win against the New York Jets, however, the offense did not perform as well as the final score indicates.

Miami only scored one offensive touchdown until the fourth quarter. However, they were able to break the game open with a 99-yard interception return for a touchdown on the final play of the first half. Additionally, Tua Tagovailoa had multiple turnovers, marking the third time in his last four games.

In three out of their last four games played outside of Florida, Miami has suffered losses. Additionally, the Dolphins will be without star linebacker Jaelan Phillips for the remainder of the season.

Green Finnian delves further into the Dolphins vs. Commanders NFL player props matchup.

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Eagles ML vs. 49ers (+126 via FanDuel) ⭐⭐⭐

Choose any widely recognized NFL betting trend, specific game scenario, or storyline, and all signs indicate a San Francisco 49ers triumph in this highly anticipated matchup that may ultimately determine the NFC’s top ranking.

After a dominating 31-13 victory over the Seattle Seahawks on Thanksgiving night, San Francisco is well-rested and eager to avenge their loss to the Philadelphia Eagles in the 2023 conference championship game. The Niners have outscored their opponents by a combined margin of 92-30 in their last three games, and they are motivated to make up for the loss that occurred when starting quarterback Brock Purdy was injured on the first series.

The Eagles have narrowly won their last few games, requiring overtime and some favorable calls from the officials to defeat the Buffalo Bills 37-34 in Week 12. This marks Philadelphia’s fourth consecutive victory by a single possession.

Philadelphia is a 3-point home underdog due to the various angles, situations, and narratives surrounding them. Despite Jalen Hurts and the Eagles not looking their best lately, they are still managing to win games. In fact, they have become just the fourth team in NFL history to win at least 10 of their first 11 contests in consecutive seasons.

In his last 30 games as a starter, Hurts has an impressive record of 27-3. He has also proven himself as an underdog, with a 1-0 record during that stretch, including a notable 21-17 victory on the road against the Kansas City Chiefs in October. This game should be considered more of a coin toss according to our top sportsbooks, making it a great opportunity to support the resilient home team.

You can pair this selection with Allen Byron’s prediction for the 49ers vs. Eagles game.

NFL upset picks were made on November 29, 2023 at 5:25 p.m. ET.

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