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Terry McLaurin celebrates after catching a touchdown reception during the third quarter of the game against the Green Bay Packers, and we offer our top NFL upset picks based on the best NFL odds.
Terry McLaurin celebrates after catching a touchdown reception during the third quarter of the game against the Green Bay Packers. Photo by Mitchell Layton/Getty Images via AFP.

After a disappointing defeat to the Buffalo Bills in Week 3, the Washington Commanders have secured a place on our list of top upset picks for Week 4 in the NFL, based on the latest odds from leading sports betting apps.

The outcomes from last week’s games were a clear illustration of the NFL’s unpredictability, as the Houston Texans, Indianapolis Colts, and Arizona Cardinals all pulled off upsets as major underdogs, with moneyline odds of +300 or more.

Who will be the one to bring the unexpected twists in this week’s NFL predictions for Week 4? Don’t forget to check out our NFL Week 4 parlay picks and player props to complete your selections.

These are our top NFL upset selections for Week 4, with odds from our recommended NFL betting sites and confidence ratings ranging from one to five stars.

NFL upset picks: Week 4

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NFL upset predictions

Washington Commanders ML vs. Philadelphia Eagles (+330 via FanDuel) ⭐⭐⭐

After suffering a devastating 34-point defeat at home, Washington is facing an uphill battle against the Eagles who are coming off a stellar performance on Monday Night Football. Despite the challenging circumstances, the Commanders are poised to be a strong candidate for an upset in Week 4, with various factors in their favor.

Washington’s 37-3 loss to Buffalo was not as bad as the final score suggested. The Commanders were within two scores of the Bills in the fourth quarter before having to abandon their productive running game due to the dwindling clock. Washington also lost the turnover battle 5-0, a situation that is unlikely to repeat in the upcoming week.

Additionally, the Commanders have demonstrated their prowess as a formidable away team in recent years. They notably thwarted the Steelers’ bid for an undefeated season in 2020 when Pittsburgh was 11-0. Furthermore, they secured a victory over the Eagles with a score of 32-21 on the same field just a year ago. The Commanders have an impressive track record, going 5-1-1 against the spread in their last seven road games, 5-2-1 as underdogs in their last eight games, and 4-1-1 in their last six visits to Philadelphia.

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Due to the Eagles having a short week and Jalen Hurts not performing at his best, there is a possibility for the Commanders to pull off a surprise victory. If you believe this could happen, be sure to compare prices at FanDuel, where they offer a price of +330, which is 20 cents higher than other top sports betting apps.

Carolina Panthers ML vs. Minnesota Vikings (+180 via DraftKings) ⭐⭐⭐

Why are bettors so eager to support the Vikings as significant road favorites in this matchup of winless teams, pushing Minnesota to -4 and -200 on the moneyline at our top sports betting sites? What exactly have the Vikings done to justify this level of confidence?

While it’s true that the Vikings have lost their first three games by a slim margin, it was anticipated that there would be a regression in close games after their impressive 11-0 record in one-score contests last season.

The Minnesota team is facing low morale after losing last week’s game on a goal-line interception. They will be three wins behind either the Packers or Lions for first place in the NFC North when this game starts, unless there is a tie in the Green Bay/Detroit game on Thursday night. The defense has struggled against both the run and the pass, allowing 259 rushing yards two weeks ago and 454 passing yards last week against the Chargers.

Carolina wasn’t anticipated to be in the playoff picture this season like the Vikings, so their 0-3 start shouldn’t be as disheartening. Instead, they should feel optimistic about their potential for an upset after putting up a strong fight against Seattle last week, staying close with a 22-20 score in the fourth quarter before ultimately falling 37-27.

If Bryce Young is unable to play for the second consecutive week, the offense could potentially benefit from having backup Andy Dalton in the lineup. Dalton demonstrated his ability by throwing for 367 yards against the Hawks.

Baltimore Ravens ML vs. Cleveland Browns (+130 via DraftKings) ⭐⭐⭐⭐

Once again facing injuries, the Ravens are underdogs as they travel to Cleveland to play for the AFC North lead against the Browns. Just like two weeks ago in Cincinnati, Baltimore has a chance to surprise everyone with another upset victory.

Baltimore’s loss to the Colts last week in overtime highlighted the impact of missing six players from the opening day lineup. Despite the Ravens’ strong performance, they could have secured a victory if they had managed the clock better in the final moments of regulation.

Under coach Jim Harbaugh, Baltimore has shown a strong ability to rebound from losses, winning their last five games in that situation with Lamar Jackson leading the team. Jackson continues to perform at a high level, showcasing his versatility by running for 101 yards and two touchdowns in addition to completing 71% of his passes in the previous game.

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Cleveland was only a 3.5-point favorite in last week’s game against Tennessee, with uncertainty among bettors about how the Browns would fare without Nick Chubb. However, the Browns proved them wrong with a dominant 27-3 victory over the Titans. Much of their offensive success can be attributed to exploiting the weaknesses of the Tennessee secondary.

Cleveland’s rushing attack faced challenges in the absence of Chubb, with featured back Jerome Ford only gaining 18 yards on 10 carries. They will feel the impact of not having that ground game prowess against Baltimore.

At this favorable price for the underdog, we are confident in supporting the Ravens to secure their 12th victory in their last 16 trips to Cleveland.

These are the NFL underdog predictions as of 09/28/2023 at 9:16 a.m. ET.

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