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The Minnesota Vikings and quarterback Joshua Dobbs are the favorite over the Chicago Bears in the NFL Week 12 odds & betting lines.
Joshua Dobbs of the Minnesota Vikings scores a touchdown against the New Orleans Saints at U.S. Bank Stadium on November 12, 2023 in Minneapolis, Minnesota. Photo by Stephen Maturen Getty Images via AFP.

Check out our breakdown of the NFL Week 12 odds and betting lines on our top NFL betting sites. The Thanksgiving games kicked off the week with excitement, and there are six divisional matchups to look forward to, including the Monday Night Football game between the Chicago Bears and Minnesota Vikings.

Despite the completion of the Week 12 holiday games, there are still six more divisional matchups on the schedule, including the highly anticipated NFC North showdown between the Chicago Bears and Minnesota Vikings to conclude the week.

The upcoming game between the Buffalo Bills and Philadelphia Eagles on Sunday is expected to be a highly anticipated matchup that could have significant implications on the Super Bowl and NFL MVP standings.

Take a detailed look at the NFL Week 12 odds provided by our top sports betting websites.

NFL Week 12 odds and lines

Betting on NFL odds becomes more challenging when trying to beat the closing line. The longer you wait to make your picks, the harder it is to find advantages and get the best numbers on side bets or totals.

It is crucial to begin monitoring the NFL opening odds weekly as early as possible to increase your chances of long-term success.

Best NFL Week 12 spreads

(Odds via Caesars)

GameSpread (Nov. 24)Spread (Nov. 21)Opening spread (Nov. 15)
Patriots vs. GiantsGiants +3Giants +3Giants +5
Panthers vs. TitansTitans -3.5Titans -3.5Titans -4
Jaguars vs. TexansTexans +1.5Texans +1.5Texans +1
Buccaneers vs. ColtsColts -2.5Colts -2.5Colts -1
Saints vs. FalconsFalcons +1.5Pick’emPick’em
Steelers vs. BengalsBengals +1.5Bengals +1Bengals -5.5
Browns vs. BroncosBroncos -1.5Broncos -2.5OTB
Rams vs. CardinalsCardinals +2.5Pick’emCardinals +2.5
Bills vs. EaglesEagles -3Eagles -3Eagles -3.5
Chiefs vs. RaidersRaiders +9Raiders +9Raiders +9.5
Ravens vs. ChargersChargers +3Chargers +3.5Chargers +3.5
Bears vs. VikingsVikings -3Vikings -3.5Vikings -4

In Week 12, there are still seven teams playing at home as underdogs, with very few large point spreads remaining. The Kansas City Chiefs are the only team favored by more than a touchdown.

Furthermore, there are 10 games remaining with the score difference at or below a field goal. It seems like it will be a fiercely competitive week.

Best NFL Week 12 moneylines

(Odds via DraftKings)

GameMoneyline (Nov. 24)Moneyline (Nov. 21)Opening moneyline (Nov. 15)
Patriots vs. GiantsGiants +150Giants +145Giants +185
Panthers vs. TitansTitans -180Titans -180Titans -192
Jaguars vs. TexansTexans +102Texans +100Texans +100
Buccaneers vs. ColtsColts -142Colts -135Colts -120
Saints vs. FalconsFalcons +105Falcons -108Falcons -110
Steelers vs. BengalsBengals +102Bengals -102Bengals -250
Browns vs. BroncosBroncos -125Broncos -135OTB
Rams vs. CardinalsCardinals +114Cardinals -105Cardinals +110
Bills vs. EaglesEagles -162Eagles -175Eagles -192
Chiefs vs. RaidersRaiders +350Raiders +310Raiders +330
Ravens vs. ChargersChargers +150Chargers +150Chargers +140
Bears vs. VikingsVikings -148Vikings -166Vikings -175

The Chiefs are the top favorite for Week 12, with many games expected to have close matchups leading to possible fluctuations in the moneylines.

Along with the significant movement leading up to the Steelers-Bengals game, the moneylines for the New York Giants and Arizona Cardinals also saw notable changes.

Best NFL Week 12 Over/Unders

(Odds via bet365)

GameOver/Unders (Nov. 24)Over/Unders (Nov. 21)Opening Over/Unders (Nov. 15)
Patriots vs. Giants34 (-110/-110)33.5 (-110/-110)35.5 (-110/-110)
Panthers vs. Titans36.5 (-110/-110)37 (-110/-110)38.5 (-110/-110)
Jaguars vs. Texans47.5 (-110/-110)48.5 (-110/-110)45.5 (-110/-110)
Buccaneers vs. Colts44.5 (-110/-110)43.5 (-110/-110)42 (-110/-110)
Saints vs. Falcons41.5 (-110/-110)42 (-110/-110)40.5 (-110/-110)
Steelers vs. Bengals35.5 (-110/-110)34.5 (-110/-110)41.5 (-110/-110)
Browns vs. Broncos36 (-110/-110)35.5 (-110/-110)OTB
Rams vs. Cardinals45 (-110/-110)44.5 (-110/-110)46 (-110/-110)
Bills vs. Eagles48.5 (-110/-110)48.5 (-110/-110)47.5 (-110/-110)
Chiefs vs. Raiders43 (-110/-110)43 (-110/-110)45 (-110/-110)
Ravens vs. Chargers48 (-110/-110)47 (-110/-110)44.5 (-110/-110)
Bears vs. Vikings43 (-110/-110)43 (-110/-110)44.5 (-110/-110)

The Week 12 opening totals were higher than usual, with several minor adjustments made to the numbers throughout the week. There are four games with totals below 40, and five games trading above the key range of 43-44.

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