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Champions League Odds & Best Bets for the Round of 16

Wright Will

Updated on February 20, 2023 at 6:19 PM EST • Read time: 3 minutes and 3 seconds. Find more on Twitter and Google News.

Manchester City manager Pep Guardiola gives instructions to Kyle Walker during a Premier League match at Tottenham Hotspur Stadium in London, England. Photo Ashley Western / Colorsport / DPPI via AFP.
Manchester City manager Pep Guardiola gives instructions to Kyle Walker during a Premier League match at Tottenham Hotspur Stadium in London, England. Photo Ashley Western / Colorsport / DPPI via AFP.

Check out the exciting matchups happening in the Champions League in the upcoming days. Below are our predictions for the Round of 16 based on the top soccer odds.

Last year’s Champions League final featured Liverpool and Real Madrid. In 2023, the two teams will face off again for a spot in the quarterfinals. The matchup between Jurgen Klopp’s team and Carlo Ancelotti’s squad is highly anticipated in European football this week. Additionally, fans can look forward to exciting games like Frankfurt vs. Napoli, Leipzig vs. City, and Inter vs. Porto.

These are our top soccer picks for the Champions League, with odds from BetMGM, DraftKings, and FanDuel. Confidence ratings range from 1 to 5 stars.

Take a look at our Champions League betting odds.

Champions League matches and odds this week 

(odds via FanDuel)

  • Liverpool (+130) vs. Real Madrid (+210) – Tuesday, 3 p.m. ET)
  • Frankfurt (+240) vs. Napoli (+110) – Tuesday, 3 p.m. ET)
  • Leipzig (+340) vs. Man City (-125) – Wednesday, 3 p.m. ET)
  • Inter (-135) vs. FC Porto (+420) – Wednesday, 3 p.m. ET)

Champions League best bets

  • Total: Liverpool vs. Real Madrid Over 2.5 (-136 via FanDuel) ⭐⭐⭐⭐
  • Spread: Manchester City -1 vs. Leipzig (+185 vs BetMGM) ⭐⭐⭐⭐
  • Moneyline: Frankfurt and Napoli to draw (+260 via DraftKings) ⭐⭐⭐
  • Parlay: Inter vs. Porto Over 0.5 first-half goals, Over 7.5 total corners, Lautaro Martinez anytime goalscorer (+280 via BetMGM) ⭐⭐⭐

Take a look at our predictions for the Real Madrid vs. Liverpool match.

Top Champions League picks

Total: Liverpool vs. Real Madrid Over 2.5 (-136) ⭐⭐⭐⭐

Soccer fans worldwide were left eagerly anticipating the Round of 16 draw. Despite the early stage of the competition, either Liverpool or Real Madrid will have to come to terms with the fact that their Champions League journey will be cut short before the quarterfinals.

Liverpool has bounced back with two impressive wins in the Premier League, relieving some of the pressure on manager Jurgen Klopp and his tactics. While they may not be at their peak form, the Anfield atmosphere can never be underestimated. With the unpredictability of this match, we recommend focusing on goal bets rather than the moneyline pick.

FanDuel is offering -136 odds for Over 2.5 goals and an attractive +190 for Over 3.5 goals. Real Madrid recently won the Club World Cup and previously triumphed in the Champions League in Paris. Liverpool will be seeking revenge for their Champions League disappointment, but Real Madrid are unfazed by such motivations. Expect plenty of goals and excitement on Tuesday evening in Liverpool.

Spread: Manchester City -1 vs. Leipzig (+185) ⭐⭐⭐⭐

Naturally, City’s goal is to win every trophy possible, with the Champions League being their main focus. Despite coming close several times after leaving FC Barcelona, manager Pep Guardiola has yet to win the prestigious tournament with Bayern or City.

Leipzig are clearly the underdogs in this upcoming match against City. City will aim to create a gap between themselves and their German rivals starting with the first leg. This would make the return match in Manchester easier for the hosts and increase their chances of achieving victory at home. The odds of City -1 vs. Leipzig are a favorable +185 through BetMGM.

Moneyline: Frankfurt and Napoli to tie (+260) ⭐⭐⭐

Do you think either of these two teams would be disappointed with a draw in the first leg? We doubt it. Napoli is performing exceptionally well at home and is on the brink of winning their first Serie A title since the Maradona era. Eintracht, the Europa League champions from last season, also have plenty to be proud of in their recent accomplishments.

This promises to be an intense battle between two formidable teams looking to establish themselves on the grand stage of European football. With odds of +260 on FanDuel, a draw is a viable choice for this game.

Parlay: Inter vs. Porto Over 0.5 first-half goals, Over 7.5 total corners, Lautaro Martinez anytime goalscorer (+280) ⭐⭐⭐

It’s no surprise they refer to them as “Crazy Inter” – the matchup between Inter and Porto promises to be wild and unpredictable. Both teams’ styles of play suggest an exciting game ahead, making it a must-watch even for neutral fans.

There is anticipation for action on both sides of the field. With Lautaro Martinez in top form, having scored four goals in his last four Serie A games, Inter’s fans are looking forward to seeing him score when Porto visits the Meazza.

Champions League betting predictions and top picks as of 2/20/2022 at 4:14 p.m. ET.

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Written By:
Wright Will
Wright Will has freelanced as a soccer specialist for the BBC, The Guardian, FourFourTwo, Goal, and the New York Times. He’s part of the “Ballon d’Or” jury, representing Romania in the vote that rewards the best soccer player in the world each year. He is based in Bucharest, Romania.