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Colombia forward Luis Diaz celebrates his penalty-kick goal against Costa Rica during the first half at State Farm Stadium as we look at our Colombia vs. Panama predictions.
Colombia forward Luis Diaz celebrates his penalty-kick goal against Costa Rica during the first half at State Farm Stadium. Photo by Daniel Bartel-USA TODAY Sports.

On Saturday, the unbeatable Colombians will take on the tournament’s underdog team in the desert. La Tricolor, who are riding high after their draw with Brazil to lead Group D, are focused on reaching the semifinals. However, the formidable Panama team poses a challenge for them at State Farm Stadium in Glendale.

Colombia has not lost a match since February 2022, making them the strong -313 favorites as they head into the quarterfinals.

Do the +1000 underdogs have a chance to pull off a surprise victory in Arizona? Find out our Colombia vs. Panama predictions using the odds from our top soccer betting websites.

Colombia vs. Panama predictions for Saturday

The odds for the Colombia vs. Panama match can be found on our top soccer betting sites, with confidence levels rated on a scale of 1 to 5 stars.

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Colombia vs. Panama score prediction

Colombia 2 vs. Panama 0

Colombia had won 10 consecutive games in all competitions before their draw with Brazil on Tuesday. They have not been defeated in their last 26 matches.

Panama has won six out of their last 10 games, but has lost four. Both teams have scored six goals in this tournament. However, Panama’s defense has been a problem as they have conceded five goals in three group games and have not kept a clean sheet in their last five matches.

Colombia will have to play without Jefferson Lerma, their key midfielder from Crystal Palace, who is serving a one-match suspension. Panama continues to be without Houston Dynamo midfielder Alberto Carrasquilla, who is still banned for receiving a red card against the USA.

Led by Liverpool’s Luis Diaz and former Real Madrid forward James Rodriguez, Colombia’s unstoppable form will prove too much for Panama in the quarterfinals of a major tournament. Though they will face a challenge, Colombia will secure their spot in the semifinals on Saturday.

A winning $10 bet with +500 odds will result in a profit of $50.

The odds of +500 on bet365 give an implied probability of 16.7%.

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Colombia vs. Panama anytime goal scorer prediction

Luis Diaz, Colombia

In his last six games for Colombia, Diaz has contributed to three goals. He scored the opening goal in their 3-0 victory over Costa Rica in the group stage of the tournament. The 27-year-old has been impressive in the three-man attack alongside James Rodriguez and Jhon Cordoba. Colombia had the highest crossing accuracy in the group stage, completing 41% of their crosses (20/49).

Rodríguez led his team with 11 successful crosses, the most of any player in the tournament after three games. Panama has conceded more goals than all but three other teams at the Copa America, making the Premier League forward confident in his ability to exploit their weak defense.

If Diaz scores, the +163 odds will result in a profit of $16.30.

Top odds: +163 at Caesars | Probability: 38%

$1,000 First Bet on Caesars

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Colombia vs. Panama best bet

Colombia wins and Under 2.5 goals

Colombia is currently tied with Argentina and Brazil for the most quarterfinal appearances at the Copa America in the last 31 years, with 12 each. In their upcoming match, Colombia will be facing a Panama team that has never advanced this far in a major tournament. The significant experience of Colombia in the knockout stage gives them a considerable advantage over Panama, known as La Tricolor.

Panama has everything to gain in this match. However, their defense has been unreliable, allowing an average of 1.6 goals per game in the tournament. On the other hand, Colombia boasts a strong offensive lineup with players like Rodriguez and Diaz.

The Colombians are currently enjoying an impressive 26-game unbeaten streak and have only allowed two goals in this tournament. Panama is considered a considerable underdog in this upcoming match. While they won’t be an easy opponent, Colombia is expected to secure a comfortable victory in Glendale on Saturday.

A $10 bet with +195 odds will result in a profit of $19.50 if successful.

Top odds: +195 on DraftKings | Equivalent probability: 33.9%

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Colombia vs. Panama odds & game info

TeamDraftKingsFanDuelBetMGMCaesarsbet365
Colombia-320-320-313 -333-333
Panama+950+950+875 ❄️+900+1000 
  • When: Saturday, July 6
  • Time: 6 p.m. ET
  • Where: State Farm Stadium, Glendale, AZ
  • How to watch: FS1, Fubo
  • Favorite: Colombia (-313 via BetMGM)

Predictions for the Colombia-Panama match were made on Friday at 3:10 p.m. ET.

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