Lionel Messi Picks, Predictions & Odds: Magical Messi Back on Home Turf

Lionel Messi scored once more as Inter Miami snapped an 11-game MLS losing streak on Saturday. Be sure to review our Lionel Messi MLS predictions for Wednesday’s Inter Miami vs. Nashville SC game, taking into account the odds from our top soccer betting platforms.

Lionel Messi is helping David Beckham in Miami establish a winning culture. In his nine games played for the new club, Messi has scored in eight of them. The Argentine has contributed 11 goals and three assists, leading the Herons to victory in the Leagues Cup, the U.S. Open Cup Final, and a two-place climb in the Major League Soccer standings from the bottom.

They are a team currently competing for a spot in the MLS playoffs, a scenario that was unimaginable just last month. Their upcoming match is against the same team they defeated in the Leagues Cup final away from home less than two weeks ago.

Check out our top pick for the Lionel Messi MLS game happening on Wednesday between Inter Miami and Nashville SC. We got the odds from our top sports betting apps and rated our confidence in the pick on a scale of 1 to 5 stars.

Lionel Messi pick: Nashville vs. Inter Miami

Messi to score 2+ goals (+270 via Caesars) ⭐⭐⭐

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Nashville SC currently ranks high in the MLS standings, leading Messi’s Miami by 17 points. Despite their strong position, it’s important not to be deceived by their recent performance. The team has suffered four consecutive losses, setting a new club record. Throughout this losing streak, they have conceded 10 goals, with four coming in their 4-0 loss to Atlanta United, the largest defeat in the club’s history.

Nashville has allowed 19 goals in 11 games, including the Leagues Cup final where Messi scored the first goal on Aug. 20. Their overall expected goals against (xGA) in MLS this season is 1.38, and on the road it’s 1.44.

Ever since Messi joined, Inter Miami hasn’t lost a single game. They have scored 27 goals in their last nine matches, compared to only 28 goals in the first 26 matches of the season before his arrival.

Miami has defeated Nashville in both cup competitions this season, triumphing on penalties in the Leagues Cup final less than two weeks ago and securing a 2-1 victory in the fifth round of the US Open Cup.

Nashville has struggled on the road this season, with three wins, three draws, and seven losses in league matches away from home. The team hasn’t won an away game in MLS since June 3rd against Dallas and has been conceding a lot of goals.

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Lionel Messi best odds

Caesars +270

This defense is tailored for Messi. Despite potentially having less playing time, he still has the ability to break through Nashville’s defense multiple times. The odds reflect this, with Caesars offering the best value at +270 compared to other main books like bet365, which has odds at +188.

The anytime scorer plays offer limited value, with the best odds at -187 from Caesars. He is listed at +200 for first scorer with four of our top sports books, while FanDuel has him as low as +175.

Miami has organized festivities for Wednesday’s game, and the team’s savior is expected to have a significant role. Despite the strong defenses in MLS, Messi is unstoppable at the moment. I predict he will dismantle Nashville’s defense.

I would give this play four stars if we knew for sure that Lionel Messi would have significant game time, especially in front of the home crowd. The opportunity is ripe for the taking.

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Nashville vs. Inter Miami game info

• Date: Wednesday, Aug. 30, 7:30 p.m. ET
• TV: Apple TV – MLS Season Pass
• Location: DRV PNK Stadium, Fort Lauderdale, FL
• Weather: 84 degrees, 47% chance of precipitation, 16-mph winds

Lionel Messi announced his pick to join MLS on August 29, 2026, at 1 p.m. Eastern Time.

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