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Darwin Nunez of Liverpool celebrates a goal 0-1 between Newcastle United and Liverpool on Feb. 18. Will the Reds emerge in our Real Madrid vs. Liverpool picks?
Darwin Nunez of Liverpool celebrates a goal 0-1 between Newcastle United and Liverpool on Feb. 18. Will the Reds emerge in our Real Madrid vs. Liverpool picks? Photo Malcolm Mackenzie / ProSportsImages / DPPI

Following the exciting match between Paris Saint-Germain and Bayern last week, the Champions League Round of 16 is heating up with another highly anticipated showdown between last year’s finalists. Real Madrid and Liverpool will battle it out for a spot in this season’s quarter-finals. Check out our predictions and picks for the match, based on the latest Champions League odds.

This season in Liverpool has been filled with controversy and criticism. Manager Jurgen Klopp has faced heavy scrutiny from both the media and some fans for his tactical decisions, which have resulted in the team being mid-table in the Premier League.

Real Madrid may not be celebrating with champagne from the Champions League trophy at the moment. Despite their recent victory in the Club World Cup, they are currently trailing FC Barcelona by eight points in the Spanish La Liga standings and are unlikely to win the title. Their upcoming Champions League campaign could be their last hope of salvaging the season.

The upcoming two-legged match between Liverpool and Real Madrid is guaranteed to make waves throughout Europe.

This is our top pick for the Real Madrid vs. Liverpool Champions League match, with odds provided by BetMGM. Our confidence in this pick is rated on a scale of 1 to 5 stars.

Take a look at our Champions League betting odds.

Real Madrid vs. Liverpool pick

Liverpool to score first vs. Real Madrid (-122 via BetMGM) ⭐⭐⭐⭐⭐

Liverpool under Klopp is defined by their enthusiasm and belief, as they have shown resilience and resourcefulness in the face of adversity. Klopp has a talent for instilling self-belief and mental strength in his team, which will be crucial in turning their season around. Even if they exit the Champions League early, Liverpool will not go down without a fight.

Real Madrid manager Carlo Ancelotti is aware of Liverpool’s tactics and knows that they will look to apply pressure from the start. This strategy has been successful in the past and is likely to be effective once again. Despite their opponents being prepared, Liverpool’s relentless attacking style is difficult to stop. Liverpool are the clear favorites to score first in this match, with odds of -122 on BetMGM providing a solid return.

Explore our Champions League odds and top bets

Real Madrid vs. Liverpool best odds

BetMGM (-122)

DraftKingsFanDuelBetMGMPointsBet
Liverpool -130Liverpool -130Liverpool -122Liverpool -130
Real +105Real +105Real +110Real +115

BetMGM has the most favorable odds at -122 for Liverpool scoring the first goal of the match. Meanwhile, DraftKings, FanDuel, and PointsBet all have the hosts at Anfield at -130. The odds for Real scoring first range from +105 to +115, with PointsBet providing the best odds.

Real Madrid vs. Liverpool game info

  • Date: Tuesday, Feb. 21, 3 p.m. ET
  • TV: fuboTV, Paramount+, CBS Sports
  • Location: Anfield Road, Liverpool, England
  • Weather: 51 degrees, 7% chance of precipitation, 8-mph winds

The Liverpool vs. Real Madrid prediction was made on February 20th, 2022 at 4:50 p.m. Eastern Time.

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