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Brock Purdy #13 of the San Francisco 49ers hands off the ball as we round up our NFL Thanksgiving predictions.
Brock Purdy #13 of the San Francisco 49ers hands off the ball to Christian McCaffrey #23 of the San Francisco 49ers during the first quarter of a game against the Tampa Bay Buccaneers at Levi’s Stadium on November 19, 2023 in Santa Clara, California. Photo by Thearon W. Henderson/Getty Images via AFP.

The 2023 NFL season kicks off Week 12 with the Thanksgiving tripleheader, and we have gathered our expert betting predictions based on the odds from the top NFL betting sites.

The NFL’s Thanksgiving tripleheader kicks off with the Green Bay Packers facing the Detroit Lions at 12:30 p.m. ET. The Dallas Cowboys will then take on the Washington Commanders at 4:30 p.m., followed by the San Francisco 49ers playing against the Seattle Seahawks at 8:20 p.m. ET to wrap up the day of football.

We are predicting the outcome of the Dolphins vs. Jets game, which will be the NFL’s first-ever Black Friday matchup, to help transition into the Sunday slate.

Explore our top NFL Thanksgiving predictions using the latest NFL Week 12 odds and betting lines.

NFL Thanksgiving schedule and odds

The current odds according to bet365 as of Tuesday at 10 a.m. ET.

NFL Thanksgiving predictions

49ers vs. Seahawks pick: Under 43.5 (-110 via DraftKings) ⭐⭐⭐

Julia Lopez predicts the outcome of the 49ers-Seahawks game.

NFL Thanksgiving promo codes

NFL expert picks for Thanksgiving

NFL betting odds pages

Check out our best NFL betting sites:

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