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Week 2 of the 2026 NFL season: Predictions, Picks, and Odds for Every Game

Evans Santiago

Updated on September 18, 2026 at 3:28 PM EDT • Read time: 1 minute and 39 seconds. Links to Twitter and Google News.

Tua Tagovailoa #1 of the Miami Dolphins signals as he returns to the field and we look at our best NFL Week 2 predictions
Tua Tagovailoa #1 of the Miami Dolphins signals as he returns to the field during a 36-34 Dolphins win over the Los Angeles Chargers at SoFi Stadium on September 10, 2026 in Inglewood, California. Photo by Harry How/Getty Images via AFP.

For those who had a successful second weekend of NFL betting or are hoping to bounce back, our predictions for the Monday Night Football doubleheader in NFL Week 2 can assist you in beating the odds from our top NFL betting sites.

Week 2 of the NFL kicked off with Thursday Night Football featuring the Philadelphia Eagles and Minnesota Vikings. The action will continue with a doubleheader on Monday night, with the New Orleans Saints taking on the Carolina Panthers and the Cleveland Browns facing the Pittsburgh Steelers in a rivalry-filled edition of Monday Night Football to wrap up the week.

Our betting experts have provided their top predictions and player props for all 16 games this week, using the NFL Week 2 odds. Get ahead of the game by checking out the NFL Week 3 odds and lines.

Week 2 NFL picks and predictions

Predictions for NFL Week 2: Sunday’s games

Pick: Over 46.5 (-110) for Dolphins vs. Patriots, rated 3 stars by BetMGM.

Kelly Gage has made her pick for the Dolphins-Patriots game.

Predictions for Monday’s NFL Week 2 games.

Pick: Under 40 points in Saints vs. Panthers game with a four-star rating, odds at -110 on DraftKings and FanDuel.

Allen Byron made the pick for the Saints-Panthers game.

Browns are the underdogs against the Steelers with a +2.5 point spread, available at -105 odds through FanDuel. This matchup is rated four stars.

Allen Byron made the Browns-Steelers pick.

Expert picks for Week 2 of the NFL season

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NFL betting odds pages

Super Bowl OddsNFL Defensive Rookie of the Year OddsNFL Sacks Leader Odds
NFL MVP OddsNFL Comeback Player of the Year OddsNFL Best Record Odds
NFL Offensive Player of the Year OddsNFL Most Regular Season Passing Yards OddsNFL Worst Record Odds
NFL Defensive Player of the Year OddsNFL Most Regular Season Rushing Yards OddsNFL Win Totals Odds
NFL Coach of the Year OddsNFL Most Regular Season Receiving Yards OddsNFL Draft Odds
NFL Offensive Rookie of the Year Odds

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Related pages

  • Top Sports Betting Websites | Top Promotions for Underscoreg (Exclusive to U.S. Players)
Written By:
Evans Santiago
Esten is the Senior Publishing Editor for UnderscoregReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with UnderscoregReview prior to the launch of sports betting in Ontario. Esten’s previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN’s Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2026 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He’s also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.