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NFL Predictions Week 6 2026: Picks & Odds for ALL Games

Evans Santiago

Updated as of October 16, 2026 at 3:42 PM EDT. Read time: 1 minute and 28 seconds. Links to Twitter and Google News provided.

General view of Buffalo Bills fans during the first half against the Miami Dolphins as we look at the top Bucs-Bills BetMGM bonus code.
General view of Buffalo Bills fans during the first half against the Miami Dolphins at Highmark Stadium in Orchard Park, New York. Photo by Timothy T Ludwig/Getty Images via AFP.

Almost every team is playing in Week 6 of the NFL, with the Sunday games kicking off in London, England. Our betting experts have made their top predictions for the week and we are ready to take advantage of the NFL odds.

The Baltimore Ravens and Tennessee Titans will face off at Tottenham Hotspur Stadium in London, England with a 9:30 a.m. ET start on Sunday morning. Later in the day, the Buffalo Bills will host the New York Giants on Sunday Night Football, while Monday Night Football will feature the Los Angeles Chargers against the struggling Dallas Cowboys.

This week, the Green Bay Packers and Pittsburgh Steelers have a bye and will not be playing.

These are our top NFL predictions for Week 6, taking into account the NFL Week 6 odds.

NFL picks and predictions for Week 6

NFL Week 6 predictions: Monday

Cowboys ML vs. Chargers pick: (-130 via bet365) ⭐⭐⭐

Allen Byron made the pick for Cowboys vs. Chargers.

NFL Week 6 expert picks

NFL promo codes Week 6

Kentucky bettors: Sports betting is here!

Kentucky sports betting officially began on September 28, so take advantage of the top Kentucky sportsbook promotions available now! Be sure to also explore our recommendations for the best Kentucky sports betting apps.

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NFL betting odds pages

Super Bowl OddsNFL Defensive Rookie of the Year OddsNFL Sacks Leader Odds
NFL MVP OddsNFL Comeback Player of the Year OddsNFL Best Record Odds
NFL Offensive Player of the Year OddsNFL Most Regular Season Passing Yards OddsNFL Worst Record Odds
NFL Defensive Player of the Year OddsNFL Most Regular Season Rushing Yards OddsNFL Win Totals Odds
NFL Coach of the Year OddsNFL Most Regular Season Receiving Yards OddsNFL Draft Odds
NFL Offensive Rookie of the Year Odds

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Written By:
Evans Santiago
Esten is the Senior Publishing Editor for UnderscoregReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with UnderscoregReview prior to the launch of sports betting in Ontario. Esten’s previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN’s Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2026 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He’s also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits still funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.